Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Combined Automated Annotation using Multiple IEA Methods
E2F transcriptional activation requires TRRAP and GCN5 cofactors.
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.
Chk2 activates E2F-1 in response to DNA damage.
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription.
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
ASPP1 and ASPP2 are new transcriptional targets of E2F.
Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.
E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation.
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.
Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.
Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F.
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1.
Regulation of E2F1 function by the nuclear corepressor KAP1.
Multimolecular complex of Par-4 and E2F1 binding to Smac promoter contributes to glutamate-induced apoptosis in human- bone mesenchymal stem cells.
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.
hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage.
Proapoptotic function of the retinoblastoma tumor suppressor protein.
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.
Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
An atlas of combinatorial transcriptional regulation in mouse and man.
E2F-1 has dual roles depending on the cell cycle.
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells.
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.
Arginine methylation controls growth regulation by E2F-1.
E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation.
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
DNA-binding specificities of human transcription factors.
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.
Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1).
Pleiotropic effect of somatic mutations in the E2F subunit DP-1 gene in human cancer.
Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A High-Density Map for Navigating the Human Polycomb Complexome.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.
A compartmentalized signaling network mediates crossover control in meiosis.
Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A protein interaction landscape of breast cancer.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Human transcription factor protein interaction networks.
Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein pocket domain.
Cloning and characterization of human DP2, a novel dimerization partner of E2F.
A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.
Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F.
DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1.
Retinoblastoma protein recruits histone deacetylase to repress transcription.
Retinoblastoma protein represses transcription by recruiting a histone deacetylase.
Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)
E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter
E2F1/2/3:DP1/2 binds EED gene promoter
E2F1/2/3:DP1/2 binds SUZ12 gene promoter
E2F1/2/3:DP1/2 binds EZH2 gene promoter
E2F1 binds BBC3 (PUMA) promoter
E2F1 binds PMAIP1 (NOXA) promoter
E2F1/3:DP1/2 binds NOTCH1 promoter
E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression
E2F1 gene transcription is inhibited by E2F6
E2F1 binds the CDC6 gene promoter
E2F1 binds the POLA1 gene promoter
E2F1 binds the PCNA gene promoter
E2F1 binds the ORC1 gene promoter
E2F1 binds the FBXO5 gene promoter
E2F1 binds the CCNE1 gene promoter
E2F1 binds the DHFR gene promoter
E2F1 binds the CCNA1 gene promoter
E2F1 binds the CDC45 gene promoter
E2F1 binds the CDK1 gene promoter
E2F1 binds the CDT1 gene promoter
E2F1 binds the CDC25A gene promoter
E2F1 binds APAF1 gene promoter
E2F1 binds RAD51 gene promoter
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes
E2F1 binds the promoter of the MYC gene
Defective RB1 does not bind E2F1,(E2F2,E2F3)
E2F1 binds the Tk1 gene promoter