The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.
You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.
We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.
We are interested in where in or outside the cell the gene product carries out its function.
We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.
Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.
The gene neur (UniProt: P29503) in Drosophila melanogaster encodes the protein Neuralized, a highly conserved E3 ubiquitin ligase that plays central roles in Notch signaling and neural development. This protein contains characteristic Neuralized Homology Repeat (NHR) domains and a C-terminal RING finger domain, consistent with the UniProt annotation for domains B30.2/SPRY_sf, NHR_dom, and Znf_RING (liu2017thenhrdomains pages 4-4, liu2017thenhrdomains pages 4-6, seib2021theroleof pages 8-9).
Neuralized functions as a RING-type E3 ubiquitin ligase with a C3HC4 RING finger domain that catalyzes the transfer of ubiquitin to lysine residues in substrate proteins (liu2017thenhrdomains pages 4-4, liu2017thenhrdomains pages 4-6, seib2021theroleof pages 8-9). The RING domain recruits ubiquitin-charged E2 enzymes and facilitates ubiquitin conjugation to target substrates, particularly the Notch ligands Delta and Serrate (liu2017thenhrdomains pages 4-6, taal2019neuralizedfamilymember pages 1-2). Recent studies from 2023 have revealed that Neuralized has a dual molecular function: it acts both as a catalytic ubiquitin ligase and as a non-catalytic endocytic adaptor (kalodimou2023separablerolesfor pages 17-19, kalodimou2023separablerolesfor pages 14-15).
The primary substrates of Neuralized are the Delta-Serrate-LAG2 (DSL) family Notch ligands, Delta (Dl) and Serrate (Ser) (liu2017thenhrdomains pages 4-4, kalodimou2023separablerolesfor pages 1-2, troost2023themeaningof pages 1-2). Neuralized preferentially ubiquitinates Delta at lysine K742, though it can modify other lysines in the Delta intracellular domain (ICD) (kalodimou2023separablerolesfor pages 17-19). Importantly, 2023 research has shown that Neuralized's interaction with Delta—rather than ubiquitination per se—is the critical requirement for basal signaling activity (kalodimou2023separablerolesfor pages 17-19, kalodimou2023separablerolesfor pages 1-2). Neuralized may also ubiquitinate other components of the Delta–Neuralized complex, potentially including itself, though the precise additional substrates remain to be fully identified (kalodimou2023separablerolesfor pages 17-19).
Neuralized possesses a modular domain architecture that integrates substrate recognition, membrane localization, oligomerization, and catalytic activity. The following table summarizes the key structural features:
| Domain/Region | Location in protein | Primary Function | Key Features |
|---|---|---|---|
| N-terminal basic region | Immediately N-terminal to NHR1; includes the basic sequence KKIKKR (residues 82–87) | Targets Neuralized to the cytoplasmic face of the plasma membrane | Binds specific plasma-membrane phospholipids, positioning Neuralized near the intracellular tails of membrane-bound Notch ligands; supports its classification as a peripheral rather than integral membrane protein (seib2021theroleof pages 8-9) |
| NHR1 (Neuralized Homology Repeat 1; Neuralized/B30.2-SPRY-like interaction domain) | First of two N-terminal NHR domains | Recognizes substrates and regulatory proteins and contributes to Neuralized oligomerization and localization | Directly binds the intracellular domains of Delta and Serrate through an NxxN Neur-box motif; also binds Bearded-family inhibitors such as Tom. Deletion or mutation of conserved G167 disrupts ligand binding, membrane localization, and Notch signaling. Its β-sandwich interaction surface includes loops L3, L5, L6, and L11 (seib2021theroleof pages 8-9, liu2017thenhrdomains pages 4-6, liu2017thenhrdomains pages 4-4, liu2017thenhrdomains pages 2-4) |
| NHR2 (Neuralized Homology Repeat 2) | Second NHR domain, between NHR1 and the C-terminal RING finger | Supports efficient ligand internalization, oligomerization, and full E3-ligase activity | Does not appear to be the principal Delta/Serrate-binding domain in Drosophila, but is required for efficient Delta endocytosis and contributes with NHR1 to homo-oligomerization. Mutation of conserved G430 impairs ubiquitination, indicating regulatory coupling to the catalytic RING domain (seib2021theroleof pages 8-9, liu2017thenhrdomains pages 4-6, liu2017thenhrdomains pages 4-4, liu2017thenhrdomains pages 2-4) |
| C3HC4 RING finger | C-terminal catalytic domain | Confers RING-type E3 ubiquitin-ligase activity | Recruits an ubiquitin-charged E2 enzyme and promotes ubiquitin transfer to lysines in substrate intracellular domains. Established targets include Delta and Serrate; Delta K742 is a preferred site in the studied Delta–Neur complex. The RING domain enhances signaling but can be dispensable for residual activity because other regions also support an endocytic-adaptor function (kalodimou2023separablerolesfor pages 17-19, seib2021theroleof pages 8-9, kalodimou2023separablerolesfor pages 15-17) |
| Full-length multidomain protein | Cytoplasmic peripheral-membrane protein associated with the plasma membrane and Delta-containing intracellular puncta/endosomal compartments | Couples substrate recognition and ubiquitination to ligand trafficking and force-generating endocytosis | NHR domains bind and organize the Delta–Neur complex, the basic region mediates membrane recruitment, and the RING finger catalyzes ubiquitination. Neuralized can co-traffic with Delta and additionally act as a non-catalytic endocytic co-adaptor, explaining why RING-deficient protein retains limited signaling activity (kalodimou2023separablerolesfor pages 14-15, kalodimou2023separablerolesfor pages 17-19) |
Table: Structural map of Drosophila Neuralized showing how its membrane-targeting sequence, two NHR interaction domains, and catalytic RING finger coordinate ligand recognition, oligomerization, ubiquitination, and endocytic trafficking.
The NHR1 domain directly binds the intracellular domains of Delta and Serrate through recognition of an NxxN consensus motif (the "Neur-box," which is NEQN in Drosophila Delta) (seib2021theroleof pages 8-9, liu2017thenhrdomains pages 4-6). This domain also interacts with Bearded-family inhibitory proteins and contributes to Neuralized homo-oligomerization (liu2017thenhrdomains pages 4-6, liu2017thenhrdomains pages 2-4). The NHR2 domain does not directly bind ligands in Drosophila but is essential for efficient Delta internalization and full E3 ligase activity (seib2021theroleof pages 8-9, liu2017thenhrdomains pages 4-6, liu2017thenhrdomains pages 4-4). Mutation of conserved glycine residues (G167 in NHR1 or G430 in NHR2) severely impairs Neuralized function (liu2017thenhrdomains pages 4-6, liu2017thenhrdomains pages 4-4, liu2017thenhrdomains pages 2-4).
Neuralized is classified as a peripheral membrane protein rather than an integral membrane protein (seib2021theroleof pages 8-9, contreras2018dynamicnotchsignalling pages 11-11, liu2017thenhrdomains pages 6-6). It localizes to the cytoplasmic face of the plasma membrane through its N-terminal basic region (residues 82-87: KKIKKR), which binds specific plasma membrane phospholipids (seib2021theroleof pages 8-9). Neuralized also localizes to intracellular endocytic vesicles and puncta, where it co-traffics with Delta through the endosomal pathway (kalodimou2023separablerolesfor pages 17-19, kalodimou2023separablerolesfor pages 14-15). This dual localization—at the plasma membrane and within endosomes—reflects Neuralized's role in both initiating and sustaining Delta endocytosis (kalodimou2023separablerolesfor pages 17-19).
Recent research has elucidated how Neuralized promotes Delta endocytosis to enable Notch receptor activation. Neuralized ubiquitinates Delta and triggers its internalization from the plasma membrane (papagiannouli2022endocytosisatthe pages 6-9, pinot2024spatiotemporalregulationof pages 8-10). This endocytosis is not merely degradative; it serves a mechanotransductive function in Notch activation (pinot2024spatiotemporalregulationof pages 8-10, kalodimou2023separablerolesfor pages 1-2, kalodimou2023separablerolesfor pages 17-19). When Delta, bound to Notch on a neighboring cell, undergoes endocytosis, it generates a pulling force on the Notch extracellular domain. This force induces a conformational change in Notch's negative regulatory region (NRR), exposing the normally buried S2 cleavage site to ADAM metalloproteases (pinot2024spatiotemporalregulationof pages 8-10, kalodimou2023separablerolesfor pages 1-2, kalodimou2023separablerolesfor pages 19-20). Subsequent proteolytic processing releases the Notch intracellular domain (NICD), which translocates to the nucleus to activate target gene expression (kalodimou2023separablerolesfor pages 1-2).
Importantly, 2023 studies have shown that Neuralized can promote Delta endocytosis through both RING-dependent and RING-independent mechanisms (kalodimou2023separablerolesfor pages 17-19, kalodimou2023separablerolesfor pages 14-15). The protein functions as an endocytic adaptor that recruits or organizes the endocytic machinery through dynamin-dependent pathways (kalodimou2023separablerolesfor pages 14-15, kalodimou2023separablerolesfor pages 17-19). Ubiquitination enhances this process but is not absolutely required for moderate signaling activity in certain developmental contexts, particularly in the central nervous system (CNS) lineages (kalodimou2023separablerolesfor pages 17-19, kalodimou2023separablerolesfor pages 1-2, kalodimou2023separablerolesfor pages 14-15).
Neuralized functions primarily within the Notch signaling pathway, where it regulates multiple developmental processes in Drosophila. The following table summarizes the major biological contexts:
| Biological process or context | Role of Neuralized (Neur) | Key mechanisms |
|---|---|---|
| Notch signaling regulation | Acts in the signal-sending cell as a positive regulator of Delta- and Serrate-dependent Notch activation. Neur combines RING-dependent E3 ubiquitin-ligase activity with a separable endocytic-adaptor function. | Neur binds DSL-ligand intracellular domains, ubiquitylates Delta and Serrate, and promotes productive ligand endocytosis. Internalization of receptor-bound ligand generates force that exposes the Notch S2 cleavage site. A Delta–Neur complex can support signaling even when Delta ubiquitylation is impaired. (seib2021theroleof pages 8-9, kalodimou2023separablerolesfor pages 1-2) |
| Neural development | Controls Delta–Notch-dependent neural-versus-nonneural fate decisions and coordinates differentiation in embryonic CNS and optic-lobe lineages. | Proneural transcriptional programs induce neur in selected cells; Neur then regulates Delta abundance and activity non-cell-autonomously. Reduced Neur activity produces neurogenic defects consistent with insufficient Notch-mediated lateral inhibition. (contreras2018dynamicnotchsignalling pages 11-11, contreras2018dynamicnotchsignalling pages 1-3, liu2017thenhrdomains pages 6-6) |
| Sensory organ development | Helps select sensory organ precursors and subsequently establishes distinct pIIa and pIIb daughter-cell identities. | During sensory-organ-precursor division, Neur becomes enriched in pIIb, where it promotes Delta endocytosis and trans-activation of Notch in pIIa. Notch-active pIIa generates external sensory cells, whereas pIIb produces internal lineage cells. (pinot2024spatiotemporalregulationof pages 1-2, pinot2024spatiotemporalregulationof pages 8-10) |
| Asymmetric cell division | Functions as an asymmetrically inherited cell-fate determinant that biases the direction of Notch signaling between daughter cells. | Neur localizes to the antero-basal cortex during mitosis and segregates preferentially into the anterior pIIb daughter at cytokinesis. Its polarized inheritance makes pIIb the Delta-sending cell and pIIa the Notch-receiving cell. (pinot2024spatiotemporalregulationof pages 8-10, pinot2024spatiotemporalregulationof pages 4-6) |
| Lateral inhibition | Strengthens signal-sending capacity in selected neural or sensory precursors, enabling them to suppress equivalent fates in neighboring cells through Notch. | Neur-dependent Delta trafficking and endocytosis support directional trans-signaling. Notch activity in adjacent cells represses proneural fate, refining spatial patterns of neural and sensory precursors. (contreras2018dynamicnotchsignalling pages 11-11, pinot2024spatiotemporalregulationof pages 1-2, papagiannouli2022endocytosisatthe pages 6-9) |
| Neural stem-cell progression | Regulates the transition of optic-lobe neuroepithelial cells through PI and PII progenitor states toward neuroblast identity. | Lethal of scute induces neur at the transition zone. Neur alters Delta levels and produces dynamic Notch activity: high in PI progenitors, reduced in PII progenitors, and elevated again after neuroblast formation. (contreras2018dynamicnotchsignalling pages 1-3) |
| Epithelial morphogenesis | Couples cell-fate specification to epithelial polarity, apical constriction, contractility, and tissue remodeling, including functions beyond canonical Delta regulation. | Neur regulates the apical Crumbs complex through Stardust isoforms and contributes to junctional myosin organization and apical constriction. Bearded-family inhibitors spatially restrain Neur activity during epithelial remodeling and furrow invagination. (pinot2024spatiotemporalregulationof pages 17-18, pinot2024spatiotemporalregulationof pages 16-17) |
Table: Summary of the principal developmental settings in which Drosophila Neuralized acts, linking each biological role to its underlying ubiquitination, endocytic, polarity, or mechanotransductive mechanism.
Neuralized plays essential roles in neural development by controlling Delta-Notch-dependent fate decisions (contreras2018dynamicnotchsignalling pages 11-11, contreras2018dynamicnotchsignalling pages 1-3, liu2017thenhrdomains pages 6-6). In the developing optic lobe, the proneural transcription factor Lethal of scute (L'sc) induces neur expression at the transition zone where neuroepithelial cells progress through progenitor states to become neuroblasts (contreras2018dynamicnotchsignalling pages 1-3). Neuralized regulates Delta levels, producing dynamic Notch activity that is high in PI progenitors, reduced in PII progenitors, and elevated again after neuroblast formation (contreras2018dynamicnotchsignalling pages 1-3). This dynamic regulation coordinates neural stem cell state progression and differentiation (contreras2018dynamicnotchsignalling pages 11-11, contreras2018dynamicnotchsignalling pages 1-3).
Neuralized functions as an asymmetrically inherited cell-fate determinant in multiple developmental contexts (pinot2024spatiotemporalregulationof pages 8-10, pinot2024spatiotemporalregulationof pages 1-2, pinot2024spatiotemporalregulationof pages 4-6). During sensory organ precursor (SOP) division, Neuralized localizes to the antero-basal cortex during mitosis and segregates preferentially into the anterior pIIb daughter cell at cytokinesis (pinot2024spatiotemporalregulationof pages 8-10). In pIIb, Neuralized ubiquitinates Delta and promotes its endocytosis, leading to trans-activation of Notch in the neighboring pIIa cell (pinot2024spatiotemporalregulationof pages 8-10). This asymmetric distribution establishes distinct daughter cell fates: Notch-active pIIa generates external sensory cells, whereas pIIb produces internal lineage cells (pinot2024spatiotemporalregulationof pages 1-2, pinot2024spatiotemporalregulationof pages 8-10).
Through its regulation of Delta trafficking and endocytosis, Neuralized strengthens the signal-sending capacity of selected neural or sensory precursors, enabling them to suppress equivalent fates in neighboring cells via Notch-mediated lateral inhibition (contreras2018dynamicnotchsignalling pages 11-11, pinot2024spatiotemporalregulationof pages 1-2, papagiannouli2022endocytosisatthe pages 6-9). This process refines spatial patterns of neural and sensory precursors during development (contreras2018dynamicnotchsignalling pages 11-11, pinot2024spatiotemporalregulationof pages 1-2).
Beyond its canonical role in Delta regulation, Neuralized contributes to epithelial polarity and morphogenesis (pinot2024spatiotemporalregulationof pages 17-18, pinot2024spatiotemporalregulationof pages 16-17). It regulates the apical Crumbs complex through specific Stardust isoforms and influences junctional myosin organization and apical constriction (pinot2024spatiotemporalregulationof pages 17-18, pinot2024spatiotemporalregulationof pages 16-17). Bearded-family proteins spatially restrain Neuralized activity during epithelial remodeling and furrow invagination (pinot2024spatiotemporalregulationof pages 17-18, pinot2024spatiotemporalregulationof pages 16-17).
Neuralized and Mindbomb1 (Mib1) are distinct E3 ubiquitin ligases that both regulate Notch ligands but through different mechanisms (guo2016structureandfunction pages 1-2, troost2023themeaningof pages 1-2, seib2021theroleof pages 8-9). While both can ubiquitinate Delta and promote Notch signaling, they are structurally unrelated and recognize non-overlapping epitopes on the ligand intracellular domain (guo2016structureandfunction pages 1-2, seib2021theroleof pages 8-9). In Drosophila, Mib1 and Neuralized act in largely complementary developmental contexts, though Neuralized can compensate for Mib1 loss in some processes such as wing development (seib2021theroleof pages 8-9).
Recent 2023-2025 research has revealed a key mechanistic distinction: Mib1-dependent Delta signaling requires ubiquitination, whereas Neuralized can activate Delta through ubiquitination-independent mechanisms (troost2023themeaningof pages 1-2, kalodimou2023separablerolesfor pages 14-15, vullings2025anothertailof pages 1-2). In Neuralized-controlled processes such as neural development, Delta can signal effectively even when intracellular lysines are mutated to prevent ubiquitination, particularly because Neuralized also functions as an endocytic co-adaptor (troost2023themeaningof pages 1-2, kalodimou2023separablerolesfor pages 14-15). By contrast, Mib1-mediated activation depends more strictly on its E3 ligase activity and Delta lysine ubiquitination (troost2023themeaningof pages 1-2, vullings2025anothertailof pages 1-2). The two ligases can act cooperatively: when Neuralized's catalytic activity is compromised, Mib1-mediated ubiquitination can enhance Delta-Neuralized signaling (kalodimou2023separablerolesfor pages 14-15, kalodimou2023separablerolesfor pages 17-19).
Bearded-family proteins function as negative regulators or inhibitors of Neuralized activity during Drosophila development (liu2017thenhrdomains pages 6-6, pinot2024spatiotemporalregulationof pages 16-17). They suppress Neuralized-mediated endocytosis of Delta and thereby modulate Delta signaling activity (liu2017thenhrdomains pages 6-6). The regulation involves a conserved Neuralized-binding motif present in both Bearded proteins and Delta, suggesting competitive or regulatory interactions through this shared binding interface (liu2017thenhrdomains pages 6-6). This regulatory mechanism provides spatial and temporal control over Neuralized function during processes such as epithelial morphogenesis and contractility (pinot2024spatiotemporalregulationof pages 16-17).
The most significant recent advances in understanding Neuralized function have come from studies published in 2023-2024 that have separated its catalytic E3 ligase activity from its non-catalytic adaptor function. Kalodimou et al. (2023) demonstrated that Neuralized's physical interaction with Delta is more critical than ubiquitination per se for basal signaling, revealing that Neuralized forms an active Delta–Neuralized signaling complex that promotes force-generating endocytosis (kalodimou2023separablerolesfor pages 17-19, kalodimou2023separablerolesfor pages 1-2). Troost et al. (2023) showed that Delta can signal without ubiquitination of its intracellular domain in Neuralized-dependent but not Mindbomb1-dependent processes, establishing Neuralized as a bifunctional protein with both enzymatic and scaffolding activities (troost2023themeaningof pages 1-2). Vüllings et al. (2025) further clarified that Delta signaling comprises multiple modes—ubiquitination-independent, Neuralized-dependent/ubiquitination-independent, and ubiquitination-dependent—that together produce full Notch activation (vullings2025anothertailof pages 1-2).
Neuralized is a multifunctional RING-type E3 ubiquitin ligase that serves as a central regulator of Notch signaling in Drosophila melanogaster. Its primary substrates are the Notch ligands Delta and Serrate, which it ubiquitinates primarily at Delta K742. Structurally, Neuralized integrates membrane targeting (via its N-terminal basic region), substrate recognition (via NHR1), oligomerization and catalytic enhancement (via NHR2), and ubiquitin ligase activity (via its C-terminal RING domain). The protein functions as both a catalytic enzyme and a non-catalytic endocytic adaptor, promoting Delta internalization through dynamin-dependent pathways. This endocytosis generates mechanical pulling forces that conformationally activate the Notch receptor in neighboring cells. Neuralized localizes to the plasma membrane and intracellular endocytic vesicles, co-trafficking with Delta through the endosomal pathway. It plays essential roles in neural development, sensory organ formation, asymmetric cell division, lateral inhibition, neural stem cell progression, and epithelial morphogenesis. Recent research has established that Neuralized can promote Notch signaling through both ubiquitination-dependent and ubiquitination-independent mechanisms, distinguishing it from the related E3 ligase Mindbomb1 and revealing the mechanistic complexity underlying developmental Notch pathway regulation.
References
(liu2017thenhrdomains pages 4-4): Sili Liu and Gabrielle L. Boulianne. The nhr domains of neuralized and related proteins: beyond notch signalling. Cellular signalling, 29:62-68, Jan 2017. URL: https://doi.org/10.1016/j.cellsig.2016.10.004, doi:10.1016/j.cellsig.2016.10.004. This article has 17 citations and is from a peer-reviewed journal.
(liu2017thenhrdomains pages 4-6): Sili Liu and Gabrielle L. Boulianne. The nhr domains of neuralized and related proteins: beyond notch signalling. Cellular signalling, 29:62-68, Jan 2017. URL: https://doi.org/10.1016/j.cellsig.2016.10.004, doi:10.1016/j.cellsig.2016.10.004. This article has 17 citations and is from a peer-reviewed journal.
(seib2021theroleof pages 8-9): Ekaterina Seib and Thomas Klein. The role of ligand endocytosis in notch signalling. Biology of the Cell, 113:401-418, Jun 2021. URL: https://doi.org/10.1111/boc.202100009, doi:10.1111/boc.202100009. This article has 44 citations and is from a peer-reviewed journal.
(taal2019neuralizedfamilymember pages 1-2): Kati Taal, Jürgen Tuvikene, Grete Rullinkov, Marko Piirsoo, Mari Sepp, Toomas Neuman, Richard Tamme, and Tõnis Timmusk. Neuralized family member neurl1 is a ubiquitin ligase for the cgmp-specific phosphodiesterase 9a. Scientific Reports, May 2019. URL: https://doi.org/10.1038/s41598-019-43069-x, doi:10.1038/s41598-019-43069-x. This article has 15 citations and is from a peer-reviewed journal.
(kalodimou2023separablerolesfor pages 17-19): Konstantina Kalodimou, Margarita Stapountzi, Nicole Vüllings, Ekaterina Seib, Thomas Klein, and Christos Delidakis. Separable roles for neur and ubiquitin in delta signalling in the drosophila cns lineages. Cells, 12:2833, Dec 2023. URL: https://doi.org/10.3390/cells12242833, doi:10.3390/cells12242833. This article has 4 citations.
(kalodimou2023separablerolesfor pages 14-15): Konstantina Kalodimou, Margarita Stapountzi, Nicole Vüllings, Ekaterina Seib, Thomas Klein, and Christos Delidakis. Separable roles for neur and ubiquitin in delta signalling in the drosophila cns lineages. Cells, 12:2833, Dec 2023. URL: https://doi.org/10.3390/cells12242833, doi:10.3390/cells12242833. This article has 4 citations.
(kalodimou2023separablerolesfor pages 1-2): Konstantina Kalodimou, Margarita Stapountzi, Nicole Vüllings, Ekaterina Seib, Thomas Klein, and Christos Delidakis. Separable roles for neur and ubiquitin in delta signalling in the drosophila cns lineages. Cells, 12:2833, Dec 2023. URL: https://doi.org/10.3390/cells12242833, doi:10.3390/cells12242833. This article has 4 citations.
(troost2023themeaningof pages 1-2): Tobias Troost, Ekaterina Seib, Alina Airich, Nicole Vüllings, Aleksandar Necakov, Stefano De Renzis, and Thomas Klein. The meaning of ubiquitylation of the dsl ligand delta for the development of drosophila. BMC Biology, Nov 2023. URL: https://doi.org/10.1186/s12915-023-01759-z, doi:10.1186/s12915-023-01759-z. This article has 9 citations and is from a domain leading peer-reviewed journal.
(liu2017thenhrdomains pages 2-4): Sili Liu and Gabrielle L. Boulianne. The nhr domains of neuralized and related proteins: beyond notch signalling. Cellular signalling, 29:62-68, Jan 2017. URL: https://doi.org/10.1016/j.cellsig.2016.10.004, doi:10.1016/j.cellsig.2016.10.004. This article has 17 citations and is from a peer-reviewed journal.
(kalodimou2023separablerolesfor pages 15-17): Konstantina Kalodimou, Margarita Stapountzi, Nicole Vüllings, Ekaterina Seib, Thomas Klein, and Christos Delidakis. Separable roles for neur and ubiquitin in delta signalling in the drosophila cns lineages. Cells, 12:2833, Dec 2023. URL: https://doi.org/10.3390/cells12242833, doi:10.3390/cells12242833. This article has 4 citations.
(contreras2018dynamicnotchsignalling pages 11-11): Esteban G. Contreras, Boris Egger, Katrina S. Gold, and Andrea H. Brand. Dynamic notch signalling regulates neural stem cell state progression in the drosophila optic lobe. Neural Development, Nov 2018. URL: https://doi.org/10.1186/s13064-018-0123-8, doi:10.1186/s13064-018-0123-8. This article has 30 citations and is from a peer-reviewed journal.
(liu2017thenhrdomains pages 6-6): Sili Liu and Gabrielle L. Boulianne. The nhr domains of neuralized and related proteins: beyond notch signalling. Cellular signalling, 29:62-68, Jan 2017. URL: https://doi.org/10.1016/j.cellsig.2016.10.004, doi:10.1016/j.cellsig.2016.10.004. This article has 17 citations and is from a peer-reviewed journal.
(papagiannouli2022endocytosisatthe pages 6-9): Fani Papagiannouli. Endocytosis at the crossroad of polarity and signaling regulation: learning from drosophila melanogaster and beyond. International Journal of Molecular Sciences, 23:4684, Apr 2022. URL: https://doi.org/10.3390/ijms23094684, doi:10.3390/ijms23094684. This article has 15 citations.
(pinot2024spatiotemporalregulationof pages 8-10): Mathieu Pinot and Roland Le Borgne. Spatio-temporal regulation of notch activation in asymmetrically dividing sensory organ precursor cells in drosophila melanogaster epithelium. Cells, 13:1133, Jun 2024. URL: https://doi.org/10.3390/cells13131133, doi:10.3390/cells13131133. This article has 3 citations.
(kalodimou2023separablerolesfor pages 19-20): Konstantina Kalodimou, Margarita Stapountzi, Nicole Vüllings, Ekaterina Seib, Thomas Klein, and Christos Delidakis. Separable roles for neur and ubiquitin in delta signalling in the drosophila cns lineages. Cells, 12:2833, Dec 2023. URL: https://doi.org/10.3390/cells12242833, doi:10.3390/cells12242833. This article has 4 citations.
(contreras2018dynamicnotchsignalling pages 1-3): Esteban G. Contreras, Boris Egger, Katrina S. Gold, and Andrea H. Brand. Dynamic notch signalling regulates neural stem cell state progression in the drosophila optic lobe. Neural Development, Nov 2018. URL: https://doi.org/10.1186/s13064-018-0123-8, doi:10.1186/s13064-018-0123-8. This article has 30 citations and is from a peer-reviewed journal.
(pinot2024spatiotemporalregulationof pages 1-2): Mathieu Pinot and Roland Le Borgne. Spatio-temporal regulation of notch activation in asymmetrically dividing sensory organ precursor cells in drosophila melanogaster epithelium. Cells, 13:1133, Jun 2024. URL: https://doi.org/10.3390/cells13131133, doi:10.3390/cells13131133. This article has 3 citations.
(pinot2024spatiotemporalregulationof pages 4-6): Mathieu Pinot and Roland Le Borgne. Spatio-temporal regulation of notch activation in asymmetrically dividing sensory organ precursor cells in drosophila melanogaster epithelium. Cells, 13:1133, Jun 2024. URL: https://doi.org/10.3390/cells13131133, doi:10.3390/cells13131133. This article has 3 citations.
(pinot2024spatiotemporalregulationof pages 17-18): Mathieu Pinot and Roland Le Borgne. Spatio-temporal regulation of notch activation in asymmetrically dividing sensory organ precursor cells in drosophila melanogaster epithelium. Cells, 13:1133, Jun 2024. URL: https://doi.org/10.3390/cells13131133, doi:10.3390/cells13131133. This article has 3 citations.
(pinot2024spatiotemporalregulationof pages 16-17): Mathieu Pinot and Roland Le Borgne. Spatio-temporal regulation of notch activation in asymmetrically dividing sensory organ precursor cells in drosophila melanogaster epithelium. Cells, 13:1133, Jun 2024. URL: https://doi.org/10.3390/cells13131133, doi:10.3390/cells13131133. This article has 3 citations.
(guo2016structureandfunction pages 1-2): Bingqian Guo, Brian J McMillan, and Stephen C Blacklow. Structure and function of the mind bomb e3 ligase in the context of notch signal transduction. Current opinion in structural biology, 41:38-45, Dec 2016. URL: https://doi.org/10.1016/j.sbi.2016.05.012, doi:10.1016/j.sbi.2016.05.012. This article has 65 citations and is from a peer-reviewed journal.
(vullings2025anothertailof pages 1-2): Nicole Vüllings, Alina Airich, Ekaterina Seib, Tobias Troost, and Thomas Klein. Another tail of two sites: activation of the notch ligand delta by mindbomb1. BMC biology, 23 1:71, Mar 2025. URL: https://doi.org/10.1186/s12915-025-02162-6, doi:10.1186/s12915-025-02162-6. This article has 1 citations and is from a domain leading peer-reviewed journal.