Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein.

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1.

Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax.

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.

Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.

Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death.

ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response.

Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim.

Heterodimerization of BAK and MCL-1 activated by detergent micelles.

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines.

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells.

Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells.

Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.

Human Bop is a novel BH3-only member of the Bcl-2 protein family.

Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1.

Placental autophagy regulation by the BOK-MCL1 rheostat.

Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells.

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination.

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Multimodal cell maps as a foundation for structural and functional genomics.

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2.

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression.

Expression of STAT3-upregulated cytosolic proteins

NPM1-ALK- and TYK2-dependent MCL1 gene expression