Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping.
Gene Ontology annotation based on curation of immunofluorescence data.
Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1.
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging.
Identification and characterization of eukaryotic initiation factor 5A-2.
Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display.
A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis.
Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.
Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A.
The effect of hypusine modification on the intracellular localization of eIF5A.
Defining the membrane proteome of NK cells.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
A proteome-scale map of the human interactome network.
Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.
Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.
eIF5A is required for autophagy by mediating ATG3 translation.
A reference map of the human binary protein interactome.
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
-
Loss-of-function eIF5A variants cause Faundes-Banka syndrome; variants reduce ribosome binding, hypusination, and polyproline translation, partially rescued by spermidine.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.
Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.
The subcellular distribution of eukaryotic translation initiation factor, eIF-5A, in cultured cells.
Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification.
Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II.
Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5.
Hypusine synthesis from eIF5A-lysine (Reactome reaction).
Hypusine synthesis from eIF5A-lysine (Reactome reaction).
Hypusine synthesis from eIF5A-lysine (Reactome reaction).
UniProt entry P63241 (IF5A1_HUMAN), Eukaryotic translation initiation factor 5A-1.
-
Translation factor that promotes translation elongation and termination, binding between the E and P sites of the ribosome and required for efficient translation of polyproline and other stalling motifs; carries the essential hypusine modification at Lys-50; predominantly cytoplasmic with XPO4-mediated nuclear shuttling.