SYNE1 review notes

2026-09-27 (claude-code)

• Core function: KASH protein of the LINC complex; KASH1 binds SUN1/SUN2 PMID:18396275;
  structures of SUN2-KASH1 and SUN1-KASH1 [PMID:22632968; PMID:33393904]. N-terminal CH domains bind actin PMID:12408964.
  -> GO:0140444 cytoskeleton-nuclear membrane anchor activity at GO:0005640 nuclear outer membrane, part of GO:0106094.
• GOA uses GO:0034993 (meiotic) for the LINC complex; evidence is somatic/structural so MODIFY -> GO:0106094 (matches module choice).
• SUN1/SUN2 protein-binding rows MODIFY -> GO:0140444; emerin, DISC1, TMEM258 rows REMOVE.
• Neuronal migration: in mouse, Syne-2 alone is essential in cortex/hippocampus; Syne-1 acts redundantly with Syne-2 in midbrain, cerebellum, hindbrain
  PMID:19874786; Syne-1 antibody co-IPs dynein from brain,
  isoform not resolved. Nesprin-1 is a weaker nucleokinesis participant in cortex than nesprin-2.
• Isoform-specific locations (Golgi, P-body, sarcomere, nucleus, lamin binding via myne-1) kept as non-core.
• Nucleolus IDA (PMID:24862572, abstract only; abstract does not mention nucleolus) left UNDECIDED.
• Falcon deep research used for muscle nuclear-shape/spacing statements (Leong 2023 via deep research).