Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A Serum Response Factor homolog is required for spore differentiation in Dictyostelium.
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DdSRF is the Dictyostelium SRF homolog with a MADS-box highly conserved with human, Drosophila and yeast SRFs.
"The MADS-box region of Dictyostelium SRF (DdSRF) is highly conserved with those of the human, Drosophila and yeast homologs"
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srfA is expressed in prespore and spore cells and is essential for sporulation; disruption causes abnormal spores and loss of viability.
"This gene plays an essential role in sporulation as its disruption leads to abnormal spore morphology and loss of viability"
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SrfA participates in regulating expression of the spore-coat marker spiA and other maturation genes.
"participates in the regulation of the expression of the spore-coat marker spiA"
The MADS-box gene srfA is expressed in a complex pattern under the control of alternative promoters and is essential for different aspects of Dictyostelium development.
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srfA is expressed in a complex, cell-type-specific pattern via alternative promoters across most cell types.
"srfA displays a complex temporal and cell type-specific pattern of expression in Dictyostelium"
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srfA is required for proper slug migration in addition to spore differentiation.
"The study of knockout strains revealed that srfA is also required for proper slug migration"
Dictyostelium discoideum developmentally regulated genes whose expression is dependent on MADS box transcription factor SrfA.
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SrfA is a MADS-box transcription factor required for spore differentiation in D. discoideum.
"The MADS box transcription factor SrfA is required for spore differentiation in Dictyostelium discoideum"
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Five SrfA-dependent genes were identified that are not expressed in srfA-null strains.
"Five genes whose expression is dependent on SrfA have been isolated by differential hybridization"
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SrfA induces spore-specific genes at the final steps of spore differentiation, possibly by direct promoter binding.
"The regulation of the expression of sig genes by SrfA could be through direct binding to their promoters, which activates their expression"
The MADS-box transcription factor SrfA is required for actin cytoskeleton organization and spore coat stability during Dictyostelium sporulation.
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srfA-null spores fail to form mature actin rods.
"SrfA mutant spores showed the initial stages of rod formation but no mature rods were found in older spores either in the nucleus or the cytoplasm"
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The spore coat outer layer progressively degrades in srfA mutants, indicating a late spore-coat stability defect.
"the outer layer gets wavier as the spore ages and suffers a progressive degradation suggesting a late defect in the stability of the spore coat"
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SrfA is involved in late events of spore maturation necessary for spore stability.
"these results suggest that SrfA is involved in late events of spore maturation necessary for spore stability"
Regulated expression of the MADS-box transcription factor SrfA mediates activation of gene expression by protein kinase A during Dictyostelium sporulation.
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PKA activation during culmination induces srfA expression in prespore cells, placing srfA downstream of PKA in spore maturation.
"Our results strongly suggest that PKA activation during culmination leads to the induction of the expression of srfA"
Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum.