Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

Falcon deep research report for human WHRN

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.

The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1.

A novel gene for Usher syndrome type 2: mutations in the long isoform of whirlin are associated with retinitis pigmentosa and sensorineural hearing loss.

MPP1 links the Usher protein network and the Crumbs protein complex in the retina.

Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.

Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules.

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.

Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2.

A reference map of the human binary protein interactome.

Quantitative fragmentomics allow affinity mapping of interactomes.