Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A physical interaction network of dengue virus and human proteins.
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.
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ANKRD50 is a new VPS35 interactor.
"This has identified a number of new interacting proteins, including ankyrin-repeat domain 50 (ANKRD50), seriologically defined colon cancer antigen 3 (SDCCAG3) and VPS9-ankyrin-repeat protein (VARP, also known as ANKRD27)."
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ANKRD50 loss diverts GLUT1 from the cell surface.
"Like suppression of VPS35, suppression of ANKRD50 resulted in a loss of GLUT1 expression at the cell surface"
Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.
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ANKRD50 is an essential component of the SNX27-retromer-WASH supercomplex.
"Here, we firmly establish ANKRD50 as a new and essential component of the SNX27-retromer-WASH super complex."
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ANKRD50 binds multiple parts of the machinery directly and cooperatively.
"Mechanistically, we show that ANKRD50 simultaneously engages multiple parts of the SNX27-retromer-WASH complex machinery in a direct and co-operative interaction network"
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VPS35 D620N weakens retromer-ANKRD50 association.
"A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's association with the WASH complex and also with the uncharacterized protein ankyrin-repeat-domain-containing protein 50 (ANKRD50)."
ANKK1, ANKRD50, GRK5, PACSIN1 and VPS8 are novel candidate genes associated with late onset Parkinson's disease: Definition of a novel predictive protocol based on polygenic model of inheritance.
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ANKRD50 is a candidate late-onset Parkinson's disease gene.
"Five of these, known as ANKK1, ANKRD50, GRK5, PACSIN1 and VPS8, were novel candidate PD genes"
UniProt entry Q9ULJ7 (ANR50_HUMAN)
Affinage mechanistic annotation for ANKRD50 (human)