GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:PSEPK/pgm/pgm-uniprot.txt

UniProt record for pgm (Q88GY7)

UniProt identifies pgm as Phosphoglucomutase (EC 5.4.2.2) and provides the seeded EC/domain/GO evidence reviewed here.

"DE EC=5.4.2.2 {ECO:0000256|NCBIfam:TIGR01132};"
InterPro assigns Q88GY7 to the alpha-D-glucose-specific phosphoglucomutase family.

"DR InterPro; IPR005852; PGM_a-D-Glc-sp."

file:PSEPK/pgm/pgm-deep-research-asta.md

Asta deep-research retrieval for pgm

Asta retrieval was run for this first-pass pathway curation; direct organism-specific literature was limited for several common enzyme names, so UniProt/family evidence carries the main review weight.

file:PSEPK/pgm/pgm-deep-research-openscientist.md

OpenScientist deep research for PSEPK pgm

Sequence/family analysis supports a dedicated glucose-specific Pgm, but no direct biochemical characterization of PP_3578 was found.

"No direct biochemical characterization of PP_3578."
Pgm links the glucose-phosphate branch point to nucleotide-sugar biosynthesis, including UDP-glucose-dependent glycan pathways.

"it functions at the **G1P/G6P branch point** that couples Entner-Doudoroff central carbon metabolism to nucleotide-sugar-dependent biosynthesis (UDP-/ADP-glucose for glycogen, trehalose, LPS/O-antigen, exopolysaccharides, and dTDP-L-rhamnose)"