GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

PMID:16077113

Localization of SpoVAD to the inner membrane of spores of Bacillus subtilis.

SpoVAD is an integral inner membrane protein present at levels >50-fold higher than nutrient germinant receptors

"SpoVAD is an integral inner membrane protein present at levels >50-fold higher than those of the spore's nutrient germinant receptors that are also present in the inner membrane"
SpoVAD persists in outgrowing spores

"SpoVAD also persisted in outgrowing spores"

file:BACSU/spoVAD/spoVAD-deep-research-falcon.md

Deep research on spoVAD gene function and literature synthesis

SpoVAD possesses a thiolase-like fold and acts as a cytoplasmic plug controlling the SpoVA channel

"Summarizes SpoVA operon (spoVAA-spoVAF) localization to inner membrane, minimal channel composition (SpoVAC + SpoVAEb + SpoVAD) and model of SpoVAD as a cytoplasmic "plug" regulating Ca-DPA accumulation/release"
The minimal SpoVA channel is composed of SpoVAC, SpoVAEb, and SpoVAD

"SpoVAF with FigP assembles an auxiliary oligomeric ion channel that amplifies germinant-triggered ion release; SpoVAC, SpoVAEb and SpoVAD comprise a minimal Ca-DPA transport module"
SpoVA proteins are localized to the spore inner membrane

"SpoVA proteins, including SpoVAD, are localized to the spore inner membrane"
GerA germinant receptors are nutrient-gated ion channels and SpoVA is required downstream for DPA export

"GerA receptors form oligomeric nutrient-gated ion channels whose ion release initiates DPA/Ca2+ mobilization from spores; SpoVA required downstream for DPA export"