Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J-type co-chaperone.
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Initial identification of human HSCB gene
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Mitochondrial targeting sequence identified
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Expression pattern similar to frataxin in mitochondria-rich tissues
Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis.
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HSCB localizes mainly to mitochondria with small amounts extra-mitochondrially
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Interacts with ISCU and HSPA9
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RNAi knockdown reduces activities of mitochondrial and cytosolic Fe-S enzymes
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Unique cysteine-rich N-terminal domain distinguishes human HSCB from fungal/bacterial homologs
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Overexpression protects cells from oxidative stress
Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).
Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.
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HSC20 C-terminus binds LYR motif-containing proteins
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LYR motifs are molecular signatures of Fe-S recipients
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HSC20 interacts with SDHB, SDHAF1, LYRM7
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HSC20 dimerization may facilitate [4Fe-4S] cluster formation
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Network of HSC20-LYR interactions key for complexes I-III assembly
A proteome-scale map of the human interactome network.
Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.
A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Deep research report on HSCB
Cyberian deep research on HSCB function