Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway.

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi.

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1.

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.

Sterol regulatory element-binding proteins are regulators of the sodium/iodide symporter in mammary epithelial cells.

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.

MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway.

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.

Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.

SREBP1A,1C,2 translocates to the nucleus

S1P hydrolyzes SREBP1A,1C,2

S2P hydrolyzes SREBP1A,1C,2

SREBP1A,1C,2:Importin beta-1 dissociates

SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers

SREBP1A,1C,2 binds Importin beta-1

SREBP1A,1C,2 binds the TM7SF2 promoter

SREBP1A,2 binds the MVD promoter

SREBP1A,1C,2 binds the FDFT1 promoter

SREBP1A,1C,2 binds the FDPS promoter

SREBP1A,1C binds the FASN promoter

SREBP1A,1C,2 binds the HMGCS1 promoter

SREBP1A,2 binds the SQLE promoter

SREBP1A,2 binds the IDI1 promoter

SREBP1A,1C binds the ACACB promoter

SREBP1A,2 binds the LSS promoter

SREBP1A,2 binds the DHCR7 promoter

SREBP1A,2 binds the PMVK promoter

SREBP1A,2 binds the MVK promoter

SREBP1A,1C binds the ACACA promoter

SREBP1A,2 binds the GGPS1 promoter

SREBP1A,2 binds the HMGCR promoter

SREBP1A,2 binds the CYP51A1 promoter

SREBP1A,2 binds the SC5DL promoter

SREBP1A,1C binds the SCD gene

Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3

SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.

Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain.

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.