Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.
Purification of proteins associated with specific genomic Loci.
NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules.
Defining the membrane proteome of NK cells.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA).
Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.
Architecture of the human interactome defines protein communities and disease networks.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Acetylation of Cytidine in mRNA Promotes Translation Efficiency.
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Antibody-based transcriptome-wide mapping identifies ac4C in human mRNA, enriched in coding sequences, and NAT10 ablation reduces the signal and destabilises the target mRNAs.
"Ablation of NAT10 reduced ac4C detection at the mapped mRNA sites and was globally associated with target mRNA downregulation."
CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation.
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Quantitative nucleotide resolution profiling of RNA cytidine acetylation by ac4C-seq.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Nucleolar maturation of the human small subunit processome.
Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
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Base-resolution RedaC:T-seq maps ac4C in HeLa mRNA and shows position-dependent effects on translation - stimulatory within coding sequences, inhibitory in 5' UTRs and AUG-flanking Kozak contexts.
"Although cytidine acetylation (ac4C) within protein-coding sequences stimulates translation, ac4C within 5' UTRs impacts protein synthesis at the level of initiation."
No evidence for ac4C within human mRNA upon data reassessment.
Detection of ac4C in human mRNA is preserved upon data reassessment.
Multimodal cell maps as a foundation for structural and functional genomics.
NAT10 promotes cisplatin resistance and immune escape by increasing the expression of DUSP1 and PD-L1 in gastric cancer.
Gasdermin C reprograms metabolism through the CAMKK2-AMPK axis to promote lung adenocarcinoma progression and radioresistance.
NAT10 deficiency in aging drives impaired liver regeneration by disrupting PARP10 in an ac4C-dependent manner.
Targeting NAT10 with Remodelin reshapes the pro-fibrotic microenvironment in renal fibrogenesis via inhibiting exosome oversecretion from tubular cells.
rRNA modification in the nucleus and cytosol
NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842