RPGRIP1L notes

Deep research: not run (falcon times out; perplexity-lite unavailable). The review uses cached publications.

Key findings

• Binds NPHP4 directly within the NPHP1-4-8 module: PMID:21565611
• TZ position distal to CEP290: PMID:28401750
• Assembly hub (worm ortholog MKS-5): PMID:26982032
• MKS and NPHP modules rely on it for TZ recruitment: PMID:28401750
• RPGR binding; the A229T modifier weakens it: PMID:19430481
• TBXA2R binding (single overexpression study): PMID:19464661

Decisions

• 7 protein binding rows REMOVE. TBXA2R binding and negative regulation of GPCR signalling kept non-core.
• NEW ciliary transition zone assembly (GO:1905349), ISS from worm MKS-5 (PMID:26982032). It passes the
  participation test as a scaffold, and CEP290, which acts downstream, already carries the term by IBA.