Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis.
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor.
Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function.
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1.
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LATS1 binds and inhibits LIMK1 to regulate cytokinesis.
"Our findings indicate that LATS1 is a novel cytoskeleton regulator that affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1."
Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
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LATS1 binds and phosphorylates YAP and retains it in the cytoplasm.
"LATS1 inactivates YAP oncogenic function by suppressing its transcription regulation of cellular genes via sequestration of YAP in the cytoplasm after phosphorylation of YAP."
Molecular characterization of human homologs of yeast MOB1.
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.
The Hippo pathway regulates Wnt/beta-catenin signaling.
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells.
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.
AMPK modulates Hippo pathway activity to regulate energy homeostasis.
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.
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LATS1/2 promote DCAF1-dependent ERalpha degradation and restrain luminal fate.
"In the presence of LATS, ERα was targeted for ubiquitination and Ddb1-cullin4-associated-factor 1 (DCAF1)-dependent proteasomal degradation."
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
Architecture of the human interactome defines protein communities and disease networks.
SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy.
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WWC proteins organize MST1/2-SAV1-mediated activation of LATS1/2.
"WWC proteins (WWC1/2/3) directly interact with LATS1/2 and SAV1, and SAV1, in turn, brings in MST1/2 to phosphorylate and activate LATS1/2."
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation.
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LATS1/2 phosphorylate NLRP3 at the MTOC to promote NEK7 binding.
"This dynamic trafficking culminates in the localization of NLRP3 to the MTOC, where LATS1/2, pre-recruited to MTOC during priming, phosphorylates NLRP3 to further facilitate its interaction with NIMA-related kinase 7 (NEK7), ultimately leading to full NLRP3 activation."
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
Phosphorylation of YAP by LATS1
Phosphorylated MOB1A proteins associate with LATS proteins
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
KIBRA (WWC1) binds LATS proteins
NPHP4 protein binds LATS proteins
Phosphorylation of WWTR1 (TAZ) by LATS1
The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.
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Capsaspora Warts (coWts) loss makes coYki nuclear but does not increase proliferation.
"Loss of coHpo or coWts does not increase cell proliferation, consistent with our previous conclusion that the Hippo pathway does not significantly affect proliferation in Capsaspora."
Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.
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Proliferation and tissue-size control by the Hippo kinase module is supported only in bilaterians.
"Thus, while the Hippo pathway is broadly conserved in animals, functional support for proliferation and tissue size control through inhibition of Yorkie by the Hippo kinase module is currently restricted to bilaterians."
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An ancestral Warts ortholog (Fonticula) can substitute for LATS1/2 in YAP/TAZ control in mammalian cells.
"the nuclear localization of YAP/TAZ in MST1/2- or LATS1/2-deficient mammalian cells can be rescued by the Acanthamoeba Hippo ortholog or the Fonticula Warts ortholog, respectively"
A fast and robust gene knockout method for <i>Salpingoeca rosetta</i> informs the genetics of choanoflagellate multicellular development
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S. rosetta warts knockout roughly doubles rosette cell number.
"warts pac1 cells grew into giant rosettes containing about twice as many cells as wild-type ones"
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S. rosetta warts knockout slows proliferation, opposite to animals.
"On the other hand, hippopac1 and warts pac1 KO clones proliferated markedly slower"