Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant.
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.
The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.
The novel human DNA helicase hFBH1 is an F-box protein.
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
TIP120A associates with cullins and modulates ubiquitin ligase activity.
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
Systematic analysis and nomenclature of mammalian F-box proteins.
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.
L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.
Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag.
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.
Identification of a primary target of thalidomide teratogenicity.
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.
Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Ubiquitin-dependent regulation of COPII coat size and function.
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase.
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
The Role of Elongin BC-Containing Ubiquitin Ligases.
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.
Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.
CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.
AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.
F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress.
The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.
Cell-fate determination by ubiquitin-dependent regulation of translation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication.
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
NRIP/DCAF6 stabilizes the androgen receptor protein by displacing DDB2 from the CUL4A-DDB1 E3 ligase complex in prostate cancer.
Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
NOTCH2 Hajdu-Cheney Mutations Escape SCF(FBW7)-Dependent Proteolysis to Promote Osteoporosis.
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.
FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.
Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2.
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.
Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice.
The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin.
DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.
The SCF(FBXO46) ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence.
Dimerization quality control ensures neuronal development and survival.
Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62.
Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15.
CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases.
A reference map of the human binary protein interactome.
The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway.
The FBXL family of F-box proteins: variations on a theme.
Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase.
DCAF14 promotes stalled fork stability to maintain genome integrity.
KDM2B Overexpression Facilitates Lytic De Novo KSHV Infection by Inducing AP-1 Activity Through Interaction with the SCF E3 Ubiquitin Ligase Complex.
FBX4 mediates rapid cyclin D1 proteolysis upon DNA damage in immortalized esophageal epithelial cells.
Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View.
OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation.
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
SCF(Fbxw5) targets kinesin-13 proteins to facilitate ciliogenesis.
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability.
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan.
Structural basis of human transcription-DNA repair coupling.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
The CRL4(DCAF1) cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle.
Diverse Roles of F-BoxProtein3 in Regulation of Various Cellular Functions.
The role of ubiquitination and deubiquitination in tumor invasion and metastasis.
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
Structure of CRL7(FBXW8) reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.
Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders.
Identification of an E3 ligase that targets the catalytic subunit of RNA Polymerase I upon transcription stress.
XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide.
The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity.
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
Molecular basis for C-degron recognition by CRL2(APPBP2) ubiquitin ligase.
ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3(KBTBD2).
Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint.
CRL3(ARMC5) ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription.
C-terminal amides mark proteins for degradation via SCF-FBXO31.
F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression.
Prolactin receptor is internalized
Proteasome proteolyzes ub-HIF-alpha
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
Nuclear VBC complex ubiquitinylates HIF-alpha
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
PRLR binds SCF beta-TrCP complex
DVL is ubiquitinated by CUL3:KLHL12:RBX1
Ubiquitinated DVL is degraded by the proteasome
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
Multi-ubiquitination of APOBEC3G
Association of APOBEC3G:Vif with the Cul5-SCF complex
Proteosome-mediated degradation of APOBEC3G
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
Degradation of ubiquitinated beta catenin by the proteasome
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
p-NICD1 PEST domain mutants do not bind FBXW7
FBXW7 WD mutants do not bind NICD1
SCF(beta-TrCP) ubiquitinates p-GLI1
SCF(beta-TrCP) ubiquitinates p-GLI3
GLI2,3 are degraded by the proteasome
phosphorylated GLI proteins bind SPOP:CUL3:RBX1
SPOP:CUL3:RBX1 ubiquitinates GLI2,3
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
KBTBD7:CUL3:RBX1 ubiquitinates NF1
Formation of the pre-incision complex in GG-NER
Recruitment of XPA and release of CAK
DNA polymerases delta, epsilon or kappa bind the GG-NER site
3'-incision of DNA by ERCC5 (XPG) in GG-NER
5'- incision of DNA by ERCC1:ERCC4 in GG-NER
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
TFIIH binds GG-NER site to form a verification complex
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site
PARP1 or PARP2 PARylates DDB2 and autoPARylates
PARP1 or PARP2 binds DDB2 at GG-NER site
CHD1L is recruited to GG-NER site
Post-translational protein modification
ERCC8 (CSA) binds stalled RNA Pol II
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
Assembly of the pre-incision complex in TC-NER
UVSSA:USP7 deubiquitinates ERCC6
ERCC2-facilitated RNA Pol II backtracking in TC-NER
ERCC5 and RPA bind TC-NER site
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
DNA polymerases delta, epsilon or kappa bind the TC-NER site
3' incision by ERCC5 (XPG) in TC-NER
Ligation of newly synthesized repair patch to incised DNA in TC-NER
Recovery of RNA synthesis after TC-NER
RNF111 ubiquitinates SUMOylated XPC
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
Ubiquitination of phosphorylated CDC25A
SCF-FBXL7 ubiquitinates AURKA
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
SCF-FBXL18 ubiquitinates FBXL7
Formation of the SCF-FBXL7 complex
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1
SCF(SKP2) complex binds RUNX2
SCF(SKP2) polyubiquitinates RUNX2
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
CAND1 binds cytosolic CRL E3 ubiquitin ligases
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
AcM-UBE2M transfers NEDD8 to CUL9:RBX1
CUL9:RBX1 ubiquitinates BIRC5
NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex
ERCC3-facilitated RNA Pol II backtracking in TC-NER
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))
BACH1:FBXL17 binds SCF(SKP2) complex
Cellular response to chemical stress
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2
NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1
MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner
26S proteasome degrades HIFalpha
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1
BTRC binds p-S344, 347 NFE2L2
Ub,pS335,S338,T NFE2L2 is degraded
CUL3:RBX1 ubiquitinates KEAP1
RBX1:CUL3 dissociates from forming autophagosome
MAP1LC3B binds KEAP1 and SQSTM1
SESN1,SESN1 bind SQSTM1 and KEAP1
Transfer of Ub from E2 to substrate and release of E2
Release of E3 from polyubiquitinated substrate
Polyubiquitination of substrate
Interaction of E3 with substrate and E2-Ub complex
Association of NS1 (1C) with Cul5 and SCF
Ubiquitination of CD274 by BTRC-SCF E3-ligase complex
Ubiquitinated CD274 is degraded by the 26S proteasome
Deubiquitination of CD274
p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex
SPOP:CUL3:RBX1 binds to CD274
SPOP-mediated degradation of CD274 by 26S Proteosome
CD274 ubiquitination by SPOP:CUL3:RBX1 complex
NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide
NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide
FBXW7 binds phosphorylated NICD1
FBXW7 mediates ubiquitination of phosphorylated NICD1
FBXW7 promotes ubiquitination of mouse p-NICD4
UniProtKB entry P62877 (RBX1), including FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, DOMAIN and SUBCELLULAR LOCATION annotations
Deep research report on human RBX1 (Edison/falcon provider)
Curator working notes for human RBX1