Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
High-resolution reconstruction of a C. elegans ribosome sheds light on evolutionary dynamics and tissue specificity.
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Cryo-EM structure of the C. elegans 80S ribosome; all ribosomal proteins except stalk proteins, eL28 and RACK-1 were modelled, so uS12 is part of the modelled 40S subunit.
"We also modeled the ribosomal proteins, with the exceptions of those bound to the P- and L-stalks (uL10/P0, P1, P2, uL1, uL11), eL28, and RACK-1"
Maternal Ribosomes Are Sufficient for Tissue Diversification during Embryonic Development in C. elegans.
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An rps-23 null allele (uS12) was generated; homozygous nulls complete embryogenesis on maternal ribosomes and then arrest as L1 larvae.
"Despite being phenotypically similar to wild-type first-stage (L1) larvae, the homozygous larvae arrest at L1 stage without any detectable growth"
Ribosomal biogenesis defects trigger subunit specific developmental checkpoints via TOR signaling and gap junction in C. elegans.
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rps-23(0) larvae arrest with partial M-cell divisions; inx-14 or sinh-1 knockdown partially rescues the arrest. Describes a ribosome-insufficiency checkpoint rather than an activity of RPS-23.
"Small subunit RP mutants rps-23(0) and rps-10(0) exhibited a less extreme phenotype"
Differential impacts of ribosomal protein haploinsufficiency on mitochondrial function.
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rps-23(0)/+ heterozygotes have about half the RPS-23 protein, altered mitochondrial morphology and a modest lifespan extension without FuDR.
"The only exception was rps-23(0)/+ mutants that displayed a modest but significant extension of lifespan only in the absence of FuDR"
A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans.
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RNAi of RPS-23 (with five other RPS proteins), used as a translation-inhibition control, caused penetrant sterility; partial depletion gave osmotically sensitive embryos without cytokinesis defects.
"Depletions of six different ribosomal subunits (RPS-1, -3, -5, -11, -18, and -23) each resulted in penetrant sterility (unpublished data)."
UniProt record Q19877 (RS23_CAEEL)
Manual literature review of rps-23
WormBase gene description for rps-23 (worm)