ECM31 (YBR176W, P38122) notes

Module context: pantothenate branch (EC 2.1.2.11, 5,10-methylene-THF + 3-methyl-2-oxobutanoate -> 2-dehydropantoate).

• PanB-family ketopantoate hydroxymethyltransferase [UniProt:P38122 "Belongs to the PanB family."]; activity inferred (EC by ECO:0000305) - no direct enzyme assay cached.
• Required for pantothenate synthesis PMID:11154694; PMID:19266201
• Mitochondrial: four HTP proteome/localisation datasets (PMID:14562095, PMID:14576278, PMID:16823961, PMID:24769239) plus IDA PMID:17054397 and plant-ortholog IBA.

Observations: YeastPathways RCA places the step in cytosol - contradicted (REMOVE). RCA CoA biosynthetic process is superpathway inflation. Open question: export of ketopantoate/pantoate from mitochondria; identity of yeast ketopantoate reductase (PAN5 is dispensable, PMID:19266201).