Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
TIP120A associates with cullins and modulates ubiquitin ligase activity.
L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.
Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.
Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins.
AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.
Widespread macromolecular interaction perturbations in human genetic disorders.
FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.
NRIP/DCAF6 stabilizes the androgen receptor protein by displacing DDB2 from the CUL4A-DDB1 E3 ligase complex in prostate cancer.
Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice.
The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin.
DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.
Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62.
Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View.
OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
The CRL4(DCAF1) cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.
Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Multimodal cell maps as a foundation for structural and functional genomics.
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
Formation of the pre-incision complex in GG-NER
Recruitment of XPA and release of CAK
DNA polymerases delta, epsilon or kappa bind the GG-NER site
3'-incision of DNA by ERCC5 (XPG) in GG-NER
5'- incision of DNA by ERCC1:ERCC4 in GG-NER
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
TFIIH binds GG-NER site to form a verification complex
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site
PARP1 or PARP2 PARylates DDB2 and autoPARylates
PARP1 or PARP2 binds DDB2 at GG-NER site
CHD1L is recruited to GG-NER site
ERCC8 (CSA) binds stalled RNA Pol II
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
Assembly of the pre-incision complex in TC-NER
UVSSA:USP7 deubiquitinates ERCC6
ERCC2-facilitated RNA Pol II backtracking in TC-NER
ERCC5 and RPA bind TC-NER site
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
DNA polymerases delta, epsilon or kappa bind the TC-NER site
3' incision by ERCC5 (XPG) in TC-NER
Ligation of newly synthesized repair patch to incised DNA in TC-NER
Recovery of RNA synthesis after TC-NER
RNF111 ubiquitinates SUMOylated XPC
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
ERCC3-facilitated RNA Pol II backtracking in TC-NER
UniProtKB Q13620: cullin-4B
CUL4B source evidence and access guide