GPX4 notes

2026-10-20 ORGANELLES batch 1 (mitochondrion rows)

• Three mitochondrion rows, all kept ACCEPT:
• IBA (PTN002613015, PTHR11592): GPX4-orthologue node (Euteleostomi) seeded by mouse and rat Gpx4;
  human GPX4 is inside the clade, no paralog transfer. propagation_review NO_FAILURE_CORE added.
• IEA GO_REF:0000120: mouse orthologue O70325 + SL-0173; human UniProt line is by similarity
  (ECO:0000250), and the human mitochondrial isoform has the N-terminal transit peptide
  (cytoplasmic isoform lacks 1-27).
• HTP MitoCoP (PMID:34800366): organelle-level.
• NEW GO:0005743 mitochondrial inner membrane (IC, isoform P36969-1). Lines of evidence:
• Sub-mitochondrial fractionation, mouse liver PMID:19447173
• Rat testis mitochondrial PHGPx PMID:7524677
  and PMID:8155669
• Leader-dependent, membrane-potential-dependent import with processing PMID:8878533
• Substrate is cardiolipin, an inner-membrane lipid PMID:19447173
  Disagreement on binding mode only (carbonate-resistant in mouse liver vs electrostatic in rat
  testis), not on the membrane. Side of the membrane unknown. Rodent data, so IC.
• core_functions.locations left as cytosol + mitochondrion: the inner-membrane location and the
  cardiolipin effect are suggestive, but the PLOOH-reducing activity has not been measured in a
  resolved inner-membrane fraction.
• Cached PMIDs 19447173, 7524677, 8155669, 8878533.