Fer1HCH (CG2216, Q7KRU8) notes

2026-10-09 review session (module dmel_ferritin_complex)

• Deep research (falcon) timed out on first attempt; rerun pending at time of review.
• Secreted 24-mer with Fer2LCH, loaded in Golgi, secreted to hemolymph
  PMID:17603097;
  PMID:26192321.
• Ferroxidase center essential in vivo
  PMID:17603097.
• Dietary iron absorption = export from enterocytes, plus tissue detoxification
  PMID:23064556.
• Iron-loaded ferritin as mitogen in culture; mutants arrest at L1
  PMID:20628369.

Decisions

• iron ion import across plasma membrane (IMP, PMID:23064556) -> MODIFY to GO:0160179 intestinal iron
  absorption: the abstract describes efflux from enterocytes, ferritin is not a plasma membrane importer.
• sleep (IEP microarray) -> MARK_AS_OVER_ANNOTATED.
• proliferation, post-embryonic development, fusome, response to fungus -> KEEP_AS_NON_CORE.
• Core: ferroxidase (GO:0004322) and iron ion sequestering activity (GO:0140315, used for human FTH1
  by IDA) within ferritin complex, Golgi and extracellular region.

Update

• Fer1HCH-deep-research-falcon.md arrived after the review (first falcon run finished late); it does not
  change the decisions above.