Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1.

Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes.

A phosphotyrosine displacement mechanism for activation of Src by PTPalpha.

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.

Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation.

Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines.

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility.

Vav2 is required for cell spreading.

Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.

Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.

Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.

ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.

Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells.

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.

The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking.

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.

Development and characterization of potent and specific peptide inhibitors of p60c-src protein tyrosine kinase using pseudosubstrate-based inhibitor design approach.

Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.

Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling.

Expression and function of RANK in human monocyte chemotaxis.

ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior.

The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.

Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex.

The role of protein-tyrosine phosphatase 1B in integrin signaling.

PTP-1B is an essential positive regulator of platelet integrin signaling.

A human protein-protein interaction network: a resource for annotating the proteome.

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.

Role of beta-arrestin 1 in the metastatic progression of colorectal cancer.

Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling.

The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling.

Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.

Ribosomal protein L10 interacts with the SH3 domain and regulates GDNF-induced neurite growth in SH-SY-5y cells.

Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.

Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.

Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.

EG-1 interacts with c-Src and activates its signaling pathway.

Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.

Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity.

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.

An inherent role of microtubule network in the action of nuclear receptor.

Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets.

Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.

PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases.

Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR.

Deciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction site.

Epidermal growth factor directs sex-specific steroid signaling through Src activation.

Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.

XB130, a novel adaptor protein for signal transduction.

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

Regulation of c-Src by binding to the PDZ domain of AF-6.

p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells.

Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation.

c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1.

PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.

Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.

Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.

Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.

Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.

Yes and PI3K bind CD95 to signal invasion of glioblastoma.

Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*.

FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse.

Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation.

TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.

The neurotransmitter dopamine modulates vascular permeability in the endothelium.

Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.

mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

PKCdelta-dependent functional switch of rpS3 between translation and DNA repair.

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.

Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.

c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.

Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis.

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells.

Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle.

Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells.

ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.

The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

The PDZ protein MPP2 interacts with c-Src in epithelial cells.

The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.

A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.

Involvement of Src tyrosine kinase in Escherichia coli invasion of human brain microvascular endothelial cells.

Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity.

JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.

Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activation.

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.

The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.

EGFR/Met association regulates EGFR TKI resistance in breast cancer.

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.

A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells.

Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.

Heme controls the regulation of protein tyrosine kinases Jak2 and Src.

Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.

VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.

Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src.

A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src.

PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis.

High-throughput RNAi screening reveals novel regulators of telomerase.

Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis.

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.

The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility.

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.

Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.

Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.

NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

Activation of rapid oestrogen signalling in aggressive human breast cancers.

VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule growth and assemble adherens junctions.

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung.

Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy.

EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.

Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.

JMJD6 regulates ERα methylation on arginine.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension.

Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).

Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

Lipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress.

A gp130-Src-YAP module links inflammation to epithelial regeneration.

Phospho-tyrosine dependent protein-protein interaction network.

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling.

PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling.

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

Roles of tau protein in health and disease.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

The Integrin Signaling Network Promotes Axon Regeneration via the Src-Ephexin-RhoA GTPase Signaling Axis.

The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release.

Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.

Quantitative fragmentomics allow affinity mapping of interactomes.

The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage.

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.

Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas.

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

Functional interaction between c-Src and its mitotic target, Sam 68.

Highly specific antibody to Rous sarcoma virus src gene product recognizes nuclear and nucleolar antigens in human cells.

Cdc2-mediated modulation of pp60c-src activity.

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.

Physical and functional association of Fc mu receptor on human natural killer cells with the zeta- and Fc epsilon RI gamma-chains and with src family protein tyrosine kinases.

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.

Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain.

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation.

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.

Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties.

Butein, a specific protein tyrosine kinase inhibitor.

Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro.

Tau interacts with src-family non-receptor tyrosine kinases.

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

SRC autophosphorylation is positively regulated by InlA-bound CDH1

Signaling by ERBB2

SRC phosphorylates SPRY2 on Y55 and Y227

Phosphorylation of JAK2

GRB2 is indirectly recruited to p-KIT through SHP2

JAK2 binds to p-KIT

Phosphorylation of GAB2 by SFKs

Recruitment of STATs

Phosphorylation of SHP2 by SFKs

Phosphorylation of APS

Synthesis of PIP3 from PIP2 by PI3K

Phosphorylation and activation of VAV1

Phosphorylation of STATs

Dimerization of STATs

Disassociation and translocation of STATs to the nucleus

Phosphorylation of p-KIT on Y900 by Src kinases

Indirect recruitment of PI3K to KIT via p(Y)-GAB2

Sustained activation of SRC kinase by SHP2

Signaling by EGFR

Phosphorylation of EGFR by SRC kinase

SH2 domain of Src binds to the active receptor

Phosphorylation of Cx43 by c-src

c-src associates with Cx43 in gap junctions

Closure of gap junction

Signaling by VEGF

SRC family kinases phosphorylate ERBB2

Cell surface interactions at the vascular wall

Sequestering and phosphorylation Fc gamma receptors in the lipid rafts

Fcgamma receptor (FCGR) dependent phagocytosis

Indirect recruitment of GAB2 to p-KIT

SHP2 interacts with p-KIT

Recruitment of CBL to KIT

Interaction of APS and p-KIT

Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src

PI3K phosphorylates PIP2 to PIP3

PI3K inhibitors block PI3K catalytic activity

EPH-Ephrin signaling

Translocation of PTK2 to Focal complexes

Autophosphorylation of PTK2 at Y397

Integrin alphaIIb beta3 activation

Recruitment of GRB2 to p-PTK2

Phosphorylation of pPTK2 by SRC

Interaction of integrin alphaIIb beta3 with Fibrinogen

Interaction of SOS with GRB2 bound to FADK1

Phosphorylation of BCAR1 by SRC-PTK2 complex

Crk binding to p130cas

Recruitment of BCAR1 to PTK2 complex

DCC interacting NCK-1

Phosphorylation of DCC by Fyn

Autophosphorylation of SRC

Clustering of Integrin alphaIIb beta3 complexes

Dephosphorylation of inactive SRC by PTPB1

Release of CSK from SRC

Activation of Src

SHP2 phosphatase binds CTLA-4

Phosphorylation of CD28

Phosphorylation of CTLA-4

Regulation of T cell activation by CD28 family

Co-stimulation by CD28

SFKs phosphorylate VAV2,3

p-EPHs bind VAV2,3

EFNB:GRB4 binds GIT1

EFNBs bind SFKs

PAKs autophosphorylate

EPHB phosphorylates TIAM1

VAV exchanges GTP for GDP on RAC1, activating it

GIT1 binds bPIX

bPIX exchanges GTP for GDP on RAC, activating it

p-EFNB binds GRB4

PAKs phosphorylate MLC

PAK binds RAC and bPIX

TIAM1 exchanges GTP for GDP on RAC1, activating it

EPHB:NMDAR binds TIAM1

NGEF exchanges GTP for GDP on RHOA

EPHA binds TIAM1

p-TIAM1 exchanges GTP for GDP on RAC1, activating it

SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)

Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)

F2R:ARRB1 binds MAPKs, SRC-1

F2R:ARRB2 binds MAPKs, SRC-1

SRC-1 bound to ARRB2 is not activated

Src activation following P2Y purinoceptor activation

Activation of Cdc42

Activation of Rac1

RhoGTPase GEF's recruited to DCC

Recruitment of Src and Fyn to DCC:FADK1

Recruitment and activation of N-WASP by Cdc42

SYK binds to integrin alphaIIb beta3

SYK activation by SRC

Activated integrin alphaIIb beta3 binds SHC1

SFKs phosphorylate PLCG1

SRC-1 phosphorylates SHB

SRC1-1 binds SH2D2A and is recruited to VEGFR2

Phosphorylation of SRC-1

GP1b signaling involves c-Src

c-Src binds Raf1

SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

SHC1 dissociates from integrin alphaIIb beta3

Phosphorylation of L1 by SRC

SRC-1 phosphorylates p-Y397-PTK2

HSP90AA1 binds p-6Y-VEGFR2

SRC-1 binds p-Y397-PTK2

PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

DOCK180:ELMO binds CRK

VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3

Src kinases phosphorylate VAV

CRK binds BCAR1 and or PXN

Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

SRC-1 phosphorylates PTK2-beta

PXN binds p-6Y,S732-PTK2

DOCK180:ELMO exchanges GTP for GDP, activating RAC1

p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407

AXL autophosphorylates on Y779 and Y821

AXL binds SRC-1

p-AXL binds PI3K

SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan

C-type lectin receptors (CLRs)

RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

Platelet activation, signaling and aggregation

2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP

SRC phosphorylates PTK2

MET phosphorylates PTK2

p-Y397-PTK2 binds SRC

InlA-mediated entry of Listeria monocytogenes into host cells

SRC phosphorylates InlA-bound CDH1 and CTNNB1

Receptor Mediated Mitophagy

RUNX3 binds SRC

SRC phosphorylates RUNX3

p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18

G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC

G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC

G protein alpha (s):GTP binds SRC

G alpha (s):GTP:SRC dissociates

G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC

Membrane estrogen receptors bind SRC

ESR-associated SRC autophosphorylates

PI3K binds membrane-associated estrogen receptors

Activated NTRK3 signals through PI3K

Activated NTRK3 binds SRC

Activated NTRK3 promotes SRC autophosphorylation

ERBB4s80 binds to SRC

PTK2 is recruited to methylated ESR1

Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers

FCGR3A-mediated IL10 synthesis

FCGR3A-mediated phagocytosis

Phosphorylation of STATs downstream of KIT mutants

JAK2 binds to p-KIT mutants

KIT mutants bind SFKs

Recruitment of STATs by KIT mutants

Dimerization of STATs downstream of KIT mutants

Phosphorylation of JAK2 downstream of KIT mutants

Disassociation and translocation of STATs to the nucleus downstream of KIT mutants

CDH1 is phosphorylated on tyrosine residues

SRC phosphorylates CDH1

SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs

Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.

Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation.

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase.

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

High-Throughput Proteomics Reveals the Unicellular Roots of Animal Phosphosignaling and Cell Differentiation.