Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
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CKAP2 colocalizes with and stabilizes microtubules
"Overexpressed Ckap2 colocalizes with and stabilizes microtubules"
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CKAP2 localizes to centrosomes and affects mitosis and cytokinesis
"In p53-null cells, overexpression of Ckap2 induces tetraploidy with aberrant centrosome numbers, suggesting disturbed mitosis and cytokinesis"
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CKAP2 activates p53-mediated apoptosis in competent cells
"In p53-competent cells, Ckap2 does not induce tetraploidy but activates p53-mediated cell cycle arrest and apoptosis"
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CKAP2 is a p53 target gene induced by DNA damage
"DNA damage induces human and mouse CKAP2 expression in a p53-dependent manner and p53 activates the Ckap2 promoter"
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CKAP2 functions in tetraploidy checkpoint and aneuploidy prevention
"Our data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint"
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
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CKAP2 identified among centrosomal proteins by proteomics
"From a background of non-specific proteins, we distinguished 126 known and 40 candidate centrosomal proteins, of which 22 were confirmed as novel components"
Deep Research Report - CKAP2 (human)
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CKAP2 is one of the most powerful microtubule nucleation and growth factors
"CKAP2 is one of the most powerful microtubule nucleation and growth factors identified: it lowers the critical tubulin concentration required for microtubule assembly by ~100-fold"
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CKAP2 strongly suppresses microtubule catastrophes and promotes growth
"CKAP2 strongly suppresses microtubule catastrophes (shrinkage events) and dramatically accelerates microtubule growth rates"
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CKAP2 is required for maintaining focused spindle poles
"CKAP2 is required for maintaining focused spindle poles and microtubule nucleation sites. CKAP2-depleted cells exhibited multipolar spindles and dispersion of microtubules"
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CKAP2 localizes dynamically during the cell cycle
"CKAP2 localizes dynamically during the cell cycle: centrosomes → spindle → chromatin → degradation, providing temporal control of microtubule organization"
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CKAP2 knockout causes chromosome segregation defects
"CKAP2 knockout cells showed reduced microtubule growth rates, increased chromosome segregation errors, and higher aneuploidy frequency"