Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.

The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic.

Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members.

Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription.

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

Control of cardiac development by an evolutionarily conserved transcriptional network.

Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.

dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development.

Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function.

Drosophila TGIF proteins are transcriptional activators.

Highwire regulates presynaptic BMP signaling essential for synaptic growth.

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.

The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary.

Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.

Identification of phosphatases for Smad in the BMP/DPP pathway.

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster.

Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism.

Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues.

A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation.

Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina.

Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation.

Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.

Distinct signaling of Drosophila Activin/TGF-beta family members.

Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction.

Mad is required for wingless signaling in wing development and segment patterning in Drosophila.

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.

A conserved activation element in BMP signaling during Drosophila development.

A transient niche regulates the specification of Drosophila intestinal stem cells.

Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis.

Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion.

Drosophila nucleoporin Nup154 controls cell viability, proliferation and nuclear accumulation of Mad transcription factor.

R-Smad competition controls activin receptor output in Drosophila.

Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand.

Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis.

Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila.

Comparative gene expression analysis of Dtg, a novel target gene of Dpp signaling pathway in the early Drosophila melanogaster embryo.

Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.

Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells.

Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic <i>Drosophila</i> retina.

Dichotomous cis-regulatory motifs mediate the maturation of the neuromuscular junction by retrograde BMP signaling.

The Integrator complex desensitizes cellular response to TGF-β/BMP signaling.

A genome-engineered tool set for Drosophila TGF-β/BMP signaling studies.

Drosophila Dpp and BMP signaling directly regulates dpp transcription for optimal ligand production.

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells.

Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye.

Characterization of Medea, a gene required for maximal function of the Drosophila BMP homolog Decapentaplegic.

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses.

The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling.

Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm.

decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.

fussel (fuss)--A negative regulator of BMP signaling in Drosophila melanogaster.

UniProt entry P42003 (MAD_DROME)