Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).

A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins.

Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication.

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation.

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.

Defining the human deubiquitinating enzyme interaction landscape.

Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis.

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.

The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.

STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.

Widespread macromolecular interaction perturbations in human genetic disorders.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.

Architecture of the human interactome defines protein communities and disease networks.

Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.

The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1.

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.

Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.

ORP9 and ORP10 form a heterocomplex to transfer phosphatidylinositol 4-phosphate at ER-TGN contact sites.

Multimodal cell maps as a foundation for structural and functional genomics.

Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.

PPM1L dephosphorylates multiphospho-CERT1-2

CERT1-2 transfers CERA from the ER membrane to the Golgi membrane

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Human VAP-C negatively regulates hepatitis C virus propagation.

UniProtKB/Swiss-Prot entry O95292 (VAPB_HUMAN)