Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification and characterization of DEDD2, a death effector domain-containing protein.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A.
HO-1 underlies resistance of AML cells to TNF-induced apoptosis.
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.
Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP.
Control of autophagic cell death by caspase-10 in multiple myeloma.
Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Casper is a FADD- and caspase-related inducer of apoptosis.
Inhibition of death receptor signals by cellular FLIP.
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
FLIP(L) and procaspase-8 form heterodimer in TNF signaling
FLIP(S) and procaspase-8 form heterodimer
Caspase-8 and FLIP(L) processing at DISC
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
FLIP(L) and procaspase-8 form heterodimer
Caspase-8 and FLIP(L) processing at TNFR signaling complex
RIPK1 is cleaved by CASP8:FLIP(L)
LUBAC ubiquitinates CFLAR at K351, K353
FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury.