Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes.
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene.
Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activation.
Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells.
Epiregulin and EGFR interactions are involved in pain processing.
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
A reference map of the human binary protein interactome.
Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family.
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.
Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.
Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin.
Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
ERBB4 binds NRGs or EGF-like ligands
SHC1 phosphorylation by ERBB2 heterodimers
Homodimerization of ERBB4
Trans-autophosphorylation of ERBB4 homodimers
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
Phosphorylation of SHC1 by ERBB4 homodimers
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
SHC1 binds P-ERBB4 isoform dimers
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
Sustained activation of SRC kinase by SHP2
Dephosphorylation of Gab1 by SHP2
SHC1 binds to the phosphorylated EGF receptor:ligand complex
Dephosphorylation of PAG by SHP2
PI3K binds to EGF:EGFR:GRB2:GAB1
GAB1 phosphorylation by EGFR kinase
SHC1 phosphorylation by phosphorylated EGFR
SHP2 dephosphorylates Tyr 992 on EGFR
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
Phosphorylation of EGFR by SRC kinase
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
GRB2:GAB1 binds to phosphorylated EGFR
GRB2:SOS1 complex binds to EGF:EGFR complex
Activation of SHP2 through the binding to phospho-Gab1
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
Phosphorylation of CBL (EGFR:CBL)
CBL-mediated ubiquitination of CIN85
Sprouty sequesters CBL away from active EGFR
Ubiquitination of stimulated EGFR (CBL)
Assembly of EGFR complex in clathrin-coated vesicles
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
Ubiquitination of stimulated EGFR (CBL:GRB2)
CBL ubiquitinates Sprouty
Phosphorylation of CBL (EGFR:GRB2:CBL)
Localization of CBL:GRB2 to the membrane
EGFR non-clathrin mediated endocytosis
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
CBL binds and ubiquitinates phosphorylated Sprouty
MATK (CSK homologous kinase) binds phosphorylated ERBB2
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
Trans-autophosphorylation of ERBB2 heterodimers
SRC family kinases phosphorylate ERBB2
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
ERBB4 forms heterodimers with ERBB3
ERBB4 forms heterodimers with EGFR
Phospholipase C-gamma1 binds to the activated EGF receptor
EGFR activates PLC-gamma1 by phosphorylation
Active PLC-gamma1 dissociates from EGFR
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
RAS GEFs promote RAS nucleotide exchange
Phosphorylated ERBB2 heterodimers bind MEMO1
MEMO1 binds RHOA:GTP:DIAPH1
Activated ERBB2 binds PTK6 (BRK)
ERBB2 promotes PTK6 autophosphorylation
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
Epsin family proteins bind ubiquitinated cargo
EGFR phosphorylates EPS15
EGFR binds EPS15, EPN1, EPS15L1
PTPN3 dephosphorylates EPS15
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
PTK2 binds activated EGFR
PTK2 autophosphorylates downstream of EGFR
Cleavage of P-ERBB4jmA isoforms by Adam17