Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structural basis for FGF receptor dimerization and activation.
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts.
Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF.
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2.
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells.
Fibroblast growth factor-2 interacts with free ribosomal protein S19.
Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development.
Translokin is an intracellular mediator of FGF-2 trafficking.
Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity.
Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.
Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.
The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity.
Klotho converts canonical FGF receptor into a specific receptor for FGF23.
Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation.
Regulation of secreted Frizzled-related protein-1 by heparin.
The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.
Active caspase-1 is a regulator of unconventional protein secretion.
Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells.
The role of syndecan-4 and attached glycosaminoglycan chains on myogenic satellite cell growth.
Crucial role of vHNF1 in vertebrate hepatic specification.
HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells.
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.
A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.
Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.
The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2.
A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF.
Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis.
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.
A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.
Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2.
Cloning and expression of cDNA encoding human basic fibroblast growth factor.
Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells.
Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation.
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
MiR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition.
The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.
Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Receptor specificity of the fibroblast growth factor family.
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes.
Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2.
Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand.
Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Activated FGFR1 mutants and fusions bind PLCG1
Activated FGFR1 mutants and fusions phosphorylate PLCG1
p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
Autocatalytic phosphorylation of FGFR4
Autocatalytic phosphorylation of FGFR3c
Autocatalytic phosphorylation of FGFR2c
Autocatalytic phosphorylation of FGFR1b
Autocatalytic phosphorylation of FGFR1c
Autocatalytic phosphorylation of FGFR3c P250R mutant
FGFR3c P250R mutant binds to ligand with enhanced affinity
FGFR1c P252X mutants bind ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
FGFR2c mutants bind an expanded range of ligands
FGFR2b mutants bind an expanded range of ligands
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
PI3K phosphorylates PIP2 to PIP3
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer
PI3K inhibitors block PI3K catalytic activity
Syndecans 1, 2, 4, (3) bind FGF2
Activated FGFR2 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR3
Activated FGFR1 phosphorylates PLCG1
Activated FGFR4 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR2
Activated FGFR2 binds PLCG1
Activated FGFR4 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR1
Activated FGFR1 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4
Activated FGFR3 phosphorylates PLCG1
Activated FGFR3 binds PLCG1
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 phosphorylates FRS2
Activated FGFR2 binds FRS2
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds SHC1
Activated FGFR2:p-SHC1 binds GRB2:SOS1
Activated FGFR2 phosphorylates SHC1
Activated FGFR3 phosphorylates FRS2
Activated FGFR3 binds FRS2
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3:pFRS binds GRB2:SOS1
Activated FGFR4 phosphorylates FRS2
Activated FGFR4 binds FRS2
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4 binds SHC1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
Activated FGFR1 binds FRS2
Activated FGFR1 binds FRS3
Activated FGFR1 binds SHC1
Activated FGFR1 phosphorylates FRS2
Activated FGFR1 phosphorylates FRS3
Activated FGFR1 phosphorylates SHC1
Activated FGFR1:p-FRS bind to PPTN11
Activated FGFR1:p-FRS binds GRB2:SOS1
Activated FGFR1:p-FRS phosphorylates PPTN11
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1:p-SHC1 binds GRB2:SOS1
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds FRS3
Activated FGFR2 phosphorylates FRS3
Activated FGFR2 phosphorylates PPTN11
Activated FGFR2:p-FRS bind to PPTN11
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR2:pFRS binds GRB2:SOS1
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 binds FRS3
Activated FGFR3 binds SHC1
Activated FGFR3 phosphorylates FRS3
Activated FGFR3 phosphorylates PPTN11
Activated FGFR3:p-FRS bind to PPTN11
Activated FGFR3 phosphorylates SHC1
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-SHC1 binds GRB2:SOS1
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 binds FRS3
Activated FGFR4 phosphorylates FRS3
Activated FGFR4 phosphorylates PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR1
p-CBL:GRB2 binds p-FRS2:activated FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
FGFR1-associated PI3K phosphorylates PIP2 to PIP3
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2-associated PI3K phosphorylates PIP2 to PIP3
FGFR3-associated PI3K phosphorylates PIP2 to PIP3
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR2
p-CBL:GRB2 binds p-FRS2:activated FGFR3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
p-4Y-PLCG1 dissociates from activated FGFR2 mutants
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3 point and translocation mutants phosphorylate PLCG1
Activated FGFR3 point and translocation mutants bind PLCG1
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants
Activated FGFR3 point, translocation and fusion mutants bind FRS2
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate FRS2
Activated FGFR1 mutants bind FRS2
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR1 mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate PLCG1
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 mutants bind FRS2
Activated FGFR2 mutants bind PLCG1
Activated FGFR1 binds FLRT1,2,3
RAS GEFs promote RAS nucleotide exchange
Expression of STAT3-upregulated extracellular proteins
FGF2:TGFBR3 binding to GIPC1
Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors
UniProt entry P09038 (FGF2_HUMAN)
Deep research report on FGF2 (Falcon)