Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator.
Activation and functional characterization of the mosaic receptor SorLA/LR11.
The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.
LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration.
The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
SorLA signaling by regulated intramembrane proteolysis.
Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.
GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production.
SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Structural basis for amyloidogenic peptide recognition by sorLA.
The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).
Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover.
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
SorLA in Interleukin-6 Signaling and Turnover.
Architecture of the human interactome defines protein communities and disease networks.
Soluble LR11 competes with amyloid β in binding to cerebrospinal fluid-high-density lipoprotein.
HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.
SORLA regulates endosomal trafficking and oncogenic fitness of HER2.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens.
SORL1 transports APP(18-770) from endosome lumen to Golgi lumen