Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry O94777 (DPM2_HUMAN)

Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.

Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.

The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.

DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3.

DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate.

dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

Defective DPM1 does not transfer mannose to DOLP to form DOLPman

Defective DPM3 does not transfer mannose to DOLP to form DOLPman

Defective DPM2 does not transfer mannose to DOLP to form DOLPman