PANTHER family review PTHR24056: IBA propagation assessment for cdc2
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.
Meiotic DNA replication checkpoint control in fission yeast.
The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts.
APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.
Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation.
Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.
Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex.
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Cdc2 is the master regulator of the cell cycle and phosphorylates the ORC subunit Orp2 as one of multiple mechanisms preventing DNA re-replication.
"Cdc2 kinase is a master regulator of cell cycle progression in the fission yeast Schizosaccharomyces pombe. Our data indicate that Cdc2 phosphorylates replication factor Orp2, a subunit of the origin recognition complex (ORC)."
In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.
Feedback regulation of the MBF transcription factor by cyclin Cig2.
CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.
Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.
A novel chk1-dependent G1/M checkpoint in fission yeast.
Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication.
Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint.
On the slowing of S phase in response to DNA damage in fission yeast.
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.
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Activating phosphorylation of Thr167 is required for p34cdc2 kinase activity at mitosis and for association with cyclin B.
"we establish that Thr167 phosphorylation is required for p34cdc2 kinase activity at mitosis and is involved in the association of p34cdc2 with cyclin B."
CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.
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Cdc2 directly phosphorylates the TOG-family protein Dis1 to regulate its localization and ensure high-fidelity chromosome segregation.
"Cdc2 thus directly phosphorylates Dis1, and this phosphorylation regulates Dis1 localization in both metaphase and anaphase and ensures high-fidelity segregation."
Phospho-regulation of the Cdc14/Clp1 phosphatase delays late mitotic events in S. pombe.
Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function.
Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast.
Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast.
Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast.
Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation.
Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.
Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation.
Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches.
Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation.
Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.
Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).
Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network.
Fission yeast cyclin: subcellular localisation and cell cycle regulation.
A PP1-PP2A phosphatase relay controls mitotic progression.
Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1.
The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization.
Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.
Regulation of p34cdc2 protein kinase during mitosis.
Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program.
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis.
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Tyr15 phosphorylation/dephosphorylation of p34cdc2 directly regulates mitotic entry; the Y15F mutant enters mitosis prematurely.
"Substitution of this tyrosine by phenylalanine advances cells prematurely into mitosis, establishing that tyrosine phosphorylation/dephosphorylation directly regulates pp34 function."
CDK Substrate Phosphorylation and Ordering the Cell Cycle.
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A single Cdc13-Cdc2 cyclin-CDK can substitute for all the cyclin-CDK complexes of the cell cycle, and a single rising CDK activity orders substrate phosphorylation via substrate-specific activity thresholds; >200 substrates were identified.
"a single rising CDK activity orders substrate phosphorylation via the sequential passage through substrate-specific activity thresholds and that this, in turn, orders cell cycle events."
The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast.
Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.
CDK contribution to DSB formation and recombination in fission yeast meiosis.
A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.
Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment.
Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast.
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Local Cdc2/MPF activity at the G2 SPB is continuously required for Plo1 association with the late-G2 SPB.
"indicating that MPF activity is continuously required for Plo1 association with the late G2 SPB"
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Active Cdc2 tethered to the SPB (via Cut12, more weakly Pcp1 or Sid4), but not elsewhere, triggers mitosis through Plo1; it acts as a trigger that converts the bulk nuclear MPF pool rather than driving division from the SPB.
"Thus, division is not driven from the SPB, rather MPF activation at the SPB serves as trigger event that promotes conversion of the bulk population MPF throughout the cell22,23 to the active state."
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NETO requires a lower threshold of MPF activity than mitotic commitment, and SPB-tethered Cdc2 induces NETO in a Plo1-dependent manner.
"indicating that the threshold of MPF activity required for NETO was lower than that for mitotic commitment"
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.
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The Suc1/Cks1 subunit (p13suc1) forms a complex with the cdc2 gene product as a regulatory component of the p34cdc2 protein kinase holoenzyme.
"p13suc1 was found in yeast lysates in a complex with the cdc2+ gene product."
Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.
Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment.
Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.
The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation.
Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe.
Differential phosphorylation of Clr4(SUV39H) by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis.
CDK actively contributes to establishment of the stationary phase state in fission yeast.
CDK phosphorylation of Sfr1 downregulates Rad51 function in late-meiotic homolog invasions.
The mitotic functions of a fission yeast CK1 enzyme are regulated by Cdk1-dependent and auto-phosphorylation.
Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast.
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cdc2 is genetically required in G1 for commitment to the cell cycle and in G2 for control of mitosis, defining its dual role at both major cell-cycle transitions.
"Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast."
The role of cdc2 and other genes in meiosis in Schizosaccharomyces pombe.
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cdc2 is essential for premeiotic DNA synthesis and meiosis II, demonstrating its requirement for the meiotic cell cycle.
"The cdc2 gene, which is required for the initiation of both mitotic S-phase and M-phase, is essential for premeiotic DNA synthesis and meiosis II."
Dominant mutants identify new roles for p34cdc2 in mitosis.
Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation.
Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.
Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis.
Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein.
Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.
Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.
Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe.
Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast.
A novel protein, Psp1, essential for cell cycle progression of Schizosaccharomyces pombe is phosphorylated by Cdc2-Cdc13 upon entry into G0-like stationary phase of cell growth.
Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.
p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle.
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation.
A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.
Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.
Negative regulation of Cdc18 DNA replication protein by Cdc2.
Cdc18 transcription and proteolysis couple S phase to passage through mitosis.