CEP97 curation notes

Deep research status

just deep-research-falcon human CEP97 was attempted (first with --fallback perplexity-lite, unavailable here; then --timeout 2400, which was killed with exit code 137). See the end of this file for the final outcome. The review was written from the cached primary literature.

Identified in CP110 complexes; recruits CP110 to centrosomes PMID:17719545
Loss causes CP110 loss, spindle defects, polyploidy PMID:17719545
Suppresses ciliogenesis with CP110 PMID:17719545
MPHOSPH9 binds CEP97 directly to anchor the cap PMID:30375385
CEP97 does not bind microtubules (unlike CP110) PMID:39847124
Also required for early stages of cilia formation in some contexts PMID:39847124

16 protein binding IPIs: REMOVE (uninformative). The CP110-recruiting function is captured by protein-macromolecule adaptor activity (IDA, ACCEPT).
Centrosome/centriole (incl. HPA GO_REF:0000052 centrosome) and negative regulation of cilium assembly: ACCEPT.
Regulation of mitotic spindle assembly: KEEP_AS_NON_CORE (likely indirect via CP110 loss).
No NEW terms (centriole-length effects of CEP97 are probably mediated by CP110; raised as a question).

Module: stage 1 CP110-CEP97 cap component ("distal centriole cap partner"), process negative regulation of cilium assembly.
HPA v25: Basal body (A), Centrosome (S), Centriolar satellite (A); main locations centriolar satellite, centrosome, cytosol. GOA carries the HPA centrosome row (GO_REF:0000052), accepted.
Assessment: consistent with the module role. The basal body call (Approved) is compatible with residual or daughter-centriole/basal-body signal in ciliated cells; the satellite pool is not explained by the module and is raised as a question. core_functions are consistent with the module (adaptor activity in negative regulation of cilium assembly at the centriole).

Falcon succeeded on the third attempt (--timeout 2400, after an exit-137 kill): CEP97-deep-research-falcon.md. Consistent with the review: CEP97-CP110 mutual dependence at distal centrioles; CEP97 has no direct microtubule activity (Iyer 2025). Additional roles noted in the description but not annotated: CP110-CEP97-CEP290 module in centrosomal aggresome assembly (Prosser 2022), DYRK1A-CEP97-PLK1 centriole disengagement in Xenopus multiciliated cells (Lee 2021), CEP97 recapping of mother centrioles in maturing mouse granule neurons (Constable 2024), and EHD1-HERC2-dependent CP110 ubiquitination during cap removal (Xie 2023).