Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II.
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The human enzyme catalyses the irreversible, NADPH-dependent conversion of testosterone to dihydrotestosterone (DHT), the most active androgen in the prostate. Biochemical dissection defined its substrate and cofactor binding sites.
"catalyses the irreversible conversion of testosterone to"
Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism.
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SRD5A2 (5 alpha-reductase 2) is the major isozyme in genital tissue; its deletion causes 5 alpha-reductase deficiency and 46,XY male pseudohermaphroditism with female external genitalia, establishing its role in male sexual differentiation.
"A deletion in this gene is present in two related individuals with male"
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
SRD5A2 dehydrogenates TEST to DHTEST
SRD5A2 binds SRD5A2 inhibitors
UniProtKB entry P31213 (S5A2_HUMAN), 3-oxo-5-alpha-steroid 4-dehydrogenase 2
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SRD5A2 catalyzes the irreversible stereospecific reduction of the Delta4,5 bond of 3-oxo steroids, converting testosterone to DHT (the most active androgen), also acting on progesterone; it is an endoplasmic reticulum / microsome multi-pass membrane protein highly expressed in the prostate and other androgen-sensitive tissues, and its variants cause male pseudohermaphroditism (5-alpha-reductase-2 deficiency).
"Catalyzes the irreversible stereospecific reduction of the"