Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

file:human/PRRT1/PRRT1-deep-research-falcon.md

Deep research report on PRRT1/SynDIG4 functional annotation

SynDIG4 is a type II transmembrane protein that functions as an AMPAR auxiliary subunit
Modulates AMPAR gating by slowing deactivation and reducing desensitization
Localized largely to intracellular and extrasynaptic compartments rather than PSD
Required for single-tetanus LTP and NMDAR-dependent LTD
Contains canonical YxxPhi endocytic motif (YVPV) that binds AP-2 mu2
Regulates AMPAR recycling via Rab4/Rab11 endosomal dynamics