Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A novel brain-expressed protein related to carnitine palmitoyltransferase I.
Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia.
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R37C mutation causes SPG73 spastic paraplegia
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CPT1C localizes to ER in motor neurons
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CPT1C interacts with ATL1 (atlastin-1)
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Mutation alters protein conformation and lipid droplet formation
Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement.
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CPT1C has palmitoyl thioesterase activity
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Catalytic triad is Ser-252, His-470, Asp-474
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CPT1C depalmitoylates GRIA1 to promote AMPAR surface expression
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Activity is specific to CPT1C isoform, not CPT1A
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CPT1C functions at ER level
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CPT1C knockout mice have diminished AMPAR surface content