Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
TreeGrafter-generated GO annotations
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.
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EPS8L2 interacts with ABI1 and SOS1, activates SOS1 Rac-GEF activity and binds actin.
"Similarly to eps8, eps8Ls interact with Abi1 and Sos-1; however, only eps8L1 and eps8L2 activate the Rac-GEF activity of Sos-1, and bind to actin in vivo."
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EPS8L2 localizes to F-actin-rich ruffles and rescues ruffling in Eps8-null fibroblasts.
"Consistently, eps8L1 and eps8L2, but not eps8L3, localize to PDGF-induced, F-actin–rich ruffles and restore receptor tyrosine kinase (RTK)-mediated actin remodeling when expressed in eps8 –/– fibroblasts."
Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
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Mouse Eps8L2 localizes at stereocilia tips and is required for long-term maintenance of the hair bundle staircase.
"We conclude that Eps8L2 is required for the long-term maintenance of the staircase structure and mechanosensory function of auditory hair bundles."
EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
UniProt record for donkey EPS8L2 (A0A9L0KBR4)
UniProt record for human EPS8L2 (Q9H6S3)
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Human EPS8L2 stimulates SOS1 exchange activity and promotes membrane ruffling and actin remodeling.
"Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton."
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EPS8L2 localizes to stereocilia tips in cochlear hair cells.
"Localizes at the tips of the stereocilia of the inner and outer hair cells."
EPS8L2: donkey-human sequence comparison