Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.
p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.
Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.
SWI/SNF chromatin remodeling and cancer.
Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.
REST repression of neuronal genes requires components of the hSWI.SNF complex.
The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.
Identification of a polymorphic, neuron-specific chromatin remodeling complex.
Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Phorbol ester-induced translocation of PKC epsilon to the nucleus in fibroblasts: identification of nuclear PKC epsilon-associating proteins.
Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis.
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.
TRPM7, a novel regulator of actomyosin contractility and cell adhesion.
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.
Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1.
Interaction of the Coxsackie and adenovirus receptor (CAR) with the cytoskeleton: binding to actin.
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
Regulation of dendritic development by neuron-specific chromatin remodeling complexes.
Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.
Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.
The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.
Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.
Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.
Catsper1 promoter is bidirectional and regulates the expression of a novel lncRNA.
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.
A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.
Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.
Critical role of TPRN rings in the stereocilia for hearing.
Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.
RalA:GTP binds Myo1c:Calm1 and F-actin
Translocation of Glut4 Vesicle and Docking at the Plasma Membrane
MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear inner hair cell
MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear outer hair cell
Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex
Dnmt3a:Dnmt3l in nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd11:Dnmt3a:Dnmt3l methylates cytosine in DNA
Formation of neural BAF (nBaf)
Falcon deep research report on mouse Actb (beta-actin, P60710)
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Beta-actin is a central component of the actin cytoskeleton, existing as monomeric (G-actin) and filamentous (F-actin) assemblies; its primary function is to polymerize into F-actin networks that drive cell motility and cytokinesis.
"β‑actin is a central component of the **actin cytoskeleton**, existing as **monomeric (G‑actin)** and **filamentous (F‑actin)** assemblies that drive processes such as **cell motility** and **cytokinesis**."
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Actin filaments are nucleated by assembly factors including formins; formin DIAPH3 preferentially generates beta-actin filaments.
"Actin filaments arise by polymerization of actin monomers and are nucleated by actin assembly factors including **formins**"
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The primary molecular function of beta-actin is to polymerize into F-actin networks that act as force-generating and scaffold structures for processes including cytokinesis.
"β‑actin’s primary functional contribution is to **polymerize into F‑actin networks** that act as force-generating and scaffold structures for cellular processes including cytokinesis"
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Beta-actin networks (but not gamma-actin) are required to maintain RhoA and activated non-muscle myosin-II at the cytokinetic furrow.
"β‑actin networks are required to maintain key contractile and signaling components at the furrow (RhoA, activated myosin-II)"
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Cytoplasmic actin isoforms form spatially distinct, functionally non-redundant networks despite minimal protein-sequence divergence (4 of 375 residues).
"**cytoplasmic actin isoforms form spatially distinct, functionally non-redundant networks** despite minimal protein sequence divergence"
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Beta-actin is enriched in specific cytoskeletal structures such as the cleavage furrow during cytokinesis.
"β‑actin can be enriched in specific cytoskeletal structures such as the **cleavage furrow** during cytokinesis"
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Actin binds and hydrolyzes ATP; the detailed ATP hydrolysis mechanism was not deeply covered in this run, but ATP binding/hydrolysis is intrinsic to actin dynamics.
"limited direct primary evidence within this run for the detailed **ATP hydrolysis mechanism** of actin"
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In retina, beta- and gamma-actin localize across retinal layers with enrichment in synaptic layers and microvilli of RPE/Muller cells; loss of beta-actin disrupts microvilli architecture and photoreceptor physiology.
"both β‑ and γ‑actin are present across retinal layers with prominent enrichment in synaptic layers and microvilli of RPE/Müller cells"
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Activation-induced homotypic clustering of CD8+ T cells requires F-actin assembly; MRTFs act as G-actin sensors driving actin gene expression.
"**activation-induced homotypic clustering** of CD8+ T cells requires **F‑actin assembly** and supports paracrine **IL‑2 retention/presentation**"
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Although ACTB/Actb is widely used as a housekeeping/reference gene, no single housekeeping gene is universally stable and ACTB should be empirically validated per tissue and condition.
"no single housekeeping gene is universally stable—hence ACTB should be empirically validated per tissue and condition"