Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.
Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytes.
Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.
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Thrombospondins bind alpha2delta-1 via EGF-like domains
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TSP1/2 deficient mice have decreased excitatory synapses
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TSP1 and TSP2 expressed during postnatal synapse formation
CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo.
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N-terminal TSP2 fragment induces CD36-dependent endothelial apoptosis
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Mechanism involves mitochondrial membrane potential loss and caspase-3 activation
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TSP2 inhibits tumor angiogenesis and metastasis in vivo
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice.
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THBS2 binds MMP2 and mediates its clearance
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Loss of THBS2 function causes ECM disorganization
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THBS2 variants cause Ehlers-Danlos-like syndrome (EDSCLL3)
PDGF binds to extracellular matrix proteins
Deep research on THBS2 function
Cyberian deep research on THBS2 function