Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.
A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.
Humanin peptide suppresses apoptosis by interfering with Bax activation.
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.
Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults.
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.
Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.
N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.
Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.
Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.
Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.
Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak.
Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.
Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.
Humanin: a novel central regulator of peripheral insulin action.
Immunolocalization of humanin in human sperm and testis.
VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.
Humanin binds MPP8: mapping interaction sites of the peptide and protein.
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.
Solution NMR structure and inhibitory effect against amyloid-β fibrillation of Humanin containing a d-isomerized serine residue.
Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.
Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.
Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.
Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.
Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.
Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.
Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.
Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
Liganded Gi-activating GPCR acts as a GEF for Gi
FPRL2 receptor binds a wide range of ligands
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
The Ligand:GPCR:Gq complex dissociates
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults.
Evidence for potential functionality of nuclearly-encoded humanin isoforms.