Exact emitted record, retrieved 2026-09-10T14:34:29.656765+00:00.
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins
UNC (CS 1) for the selected G3V4H1 product. The “lacks intrinsic GTPase activity” description is contradicted for full-length RHOJ by direct hydrolysis measurements, but the target has a divergent, incomplete G-domain. The conjunction “binds GTP but lacks hydrolysis and resists GAPs” requires binding, hydrolysis and GAP assays of this exact product; a truncation alone does not establish an atypical GTPase mechanism. PMID:10967094(https://pubmed.ncbi.nlm.nih.gov/10967094/); sequence mapping.
The assessment concerns the selected accession G3V4H1. Other emitted outputs and evidence context.