Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Development of a yeast-based system to identify new hBRAFV600E functional interactors.
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SMIM10 was recovered in a yeast screen as a suppressor of BRAF V600E toxicity. When overexpressed in BRAF V600E melanoma cells it indirectly lowers BRAF V600E RNA and protein levels.
"we identify SMIM10, a mitochondrial protein that in melanoma cells selectively downregulates BRAFV600E RNA and protein levels, by acting indirectly at the post-transcriptional level."
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SMIM10 overexpression disrupts mitochondria and induces senescence in BRAF V600E melanoma cells.
"Upon SMIM10 overexpression, BRAFV600E melanoma cells show disrupted mitochondrial structure/function and undergo senescence."
UniProtKB/Swiss-Prot entry Q96HG1 (SIM10_HUMAN)