Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease cases.
Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells.
Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal.
Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium.
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.
The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line.
The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization.
Regulation of M₃ muscarinic receptor expression and function by transmembrane protein 147.
Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes.
Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.
Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins.
The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line.
Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors.
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
CHRM1,3,5 bind acetylcholine
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
The Ligand:GPCR:Gq complex dissociates
CHRM1,3,5 bind CHRM1,3,5 antagonists
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Curated UniProt record for human CHRM3
Agonist-selective activation of individual G-proteins by muscarinic receptors.
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Full primary source: human M2-Gi/o activation and M1/M3-Gq/11 profiling in engineered expression systems. Ligand, expression, cofactor and assay context affect coupling. It does not directly assay every receptor-G-protein-effector combination.
Gq/11 and Gi/o activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype
Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications.
The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β-cell line
Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells.
Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies.
M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.
Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice.