Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas.
Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins.
Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb.
RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein.
A novel Rb- and p300-binding protein inhibits transactivation by MyoD.
Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation.
The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein.
Physical interaction between pRb and cdk9/cyclinT2 complex.
Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo.
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.
Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha.
The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex.
Interaction of the HPV E7 proteins with the pCAF acetyltransferase.
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins.
LEK1 is a potential inhibitor of pocket protein-mediated cellular processes.
Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation.
Cyclin C/cdk3 promotes Rb-dependent G0 exit.
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.
Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation.
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.
Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.
Effects of MdmX on Mdm2-mediated downregulation of pRB.
The arginine methyltransferase PRMT2 binds RB and regulates E2F function.
Roles for APIS and the 20S proteasome in adenovirus E1A-dependent transcription.
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
Prohibitin, a protein downregulated by androgens, represses androgen receptor activity.
p53 family members in myogenic differentiation and rhabdomyosarcoma development.
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
L3MBTL1, a histone-methylation-dependent chromatin lock.
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1.
EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes.
Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product.
Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein.
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.
Proapoptotic function of the retinoblastoma tumor suppressor protein.
Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice.
Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis.
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.
Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Loss of pRB causes centromere dysfunction and chromosomal instability.
Methylation of the retinoblastoma tumor suppressor by SMYD2.
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.
Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine.
The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.
The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.
Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.
The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein.
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.
LEDGF (p75) promotes DNA-end resection and homologous recombination.
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.
The protein interaction landscape of the human CMGC kinase group.
The functional interactome landscape of the human histone deacetylase family.
Modulation of allostery by protein intrinsic disorder.
Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells.
MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons.
HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator.
Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
Phospho-tyrosine dependent protein-protein interaction network.
Homology between a region of the human retinoblastoma gene and L1 family repetitive sequences.
A compartmentalized signaling network mediates crossover control in meiosis.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
A protein interaction landscape of breast cancer.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Human transcription factor protein interaction networks.
The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity.
Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein pocket domain.
Multimodal cell maps as a foundation for structural and functional genomics.
Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast.
Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element.
Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression.
The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.
Interaction between the retinoblastoma protein and the oncoprotein MDM2.
Binding of an interferon-inducible protein (p202) to the retinoblastoma protein.
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest.
Structural and functional characterization of the HPV16 E7 protein expressed in bacteria.
Identification of discrete structural domains in the retinoblastoma protein. Amino-terminal domain is required for its oligomerization.
Cyclin-binding motifs are essential for the function of p21CIP1.
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
A DNA polymerase alpha accessory protein exhibits structural and functional similarities to SV40 large tumor antigen.
Phosphorylated retinoblastoma protein stimulates DNA polymerase alpha.
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein.
Retinoblastoma protein recruits histone deacetylase to repress transcription.
Retinoblastoma protein represses transcription by recruiting a histone deacetylase.
The rubella virus putative replicase interacts with the retinoblastoma tumor suppressor protein.
A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.
Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250.
Direct suppression of Stat1 function during adenoviral infection.
PP2A mediated localization of RB1 protein in chromatin
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
APC/C:Cdh1-mediated degradation of Skp2
Association of Rb with Cyclin E:Cdk2 complexes
Cyclin E:CDK2-mediated phosphorylation of RB1
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes
Defective RB1 does not bind E2F1,(E2F2,E2F3)
RB1 translocates to the nucleus
Defective RB1 does not translocate to the nucleus
APC/C:Cdh1 polyubiquitinates SKP2
RB1 recruits APC/C:Cdh1 complex to SKP2
Defective RB1 does not form a complex with SKP2 and FZR1
RB1 and TFAP2A bind CDH1 gene promoter
NPM1-ALK-dependent repression of pRB phosphorylation
Runx2:RB1 binds the BGLAP gene promoter
RB1 deep research (falcon, 2024 reviews synthesis)