Calm1 Notes

2026-03-19

• Calm1 encodes canonical calmodulin, a four-EF-hand calcium sensor whose sequence is shared with Calm2 and Calm3; the most defensible gene-specific distinctions for mouse Calm1 are regulatory rather than protein-sequence based [file:mouse/Calm1/Calm1-deep-research-falcon.md "Calm1's distinctive biological role is likely driven by mRNA-level regulation (APA-dependent UTRs, stability, and neuronal localization)"].
• Cached literature supports broad core CaM functions rather than a narrow enzyme-like role: altered CaM levels change progression through G1 and mitosis in mouse cells PMID:2469574.
• CaM directly modulates intracellular calcium-release pathways; IP3-receptor-mediated calcium mobilization is inhibited by calmodulin across receptor subtypes PMID:10620513.
• CaM also behaves as a constitutive auxiliary channel subunit in neurons, with KCNQ2/3 current depending on CaM binding PMID:12223552.
• Synaptic membrane trafficking is another supported non-core but plausible neuronal context: calmodulin knockout impaired multiple forms of endocytosis in hippocampal synapses PMID:31628181.
• Mouse-specific follow-up worth keeping in mind for future review refinement: the deep-research summary points to Calm1-S and Calm1-L 3' UTR isoforms, with neural enrichment of the long isoform and phenotypes after distal poly(A) site deletion [file:mouse/Calm1/Calm1-deep-research-falcon.md "Calm1 has strong post-transcriptional regulation via alternative polyadenylation. It produces Calm1-S and Calm1-L transcripts with identical coding sequence but distinct 3' UTRs."].