Annotation inferences using phylogenetic trees
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Multiple IBA annotations derived from PANTHER phylogenetic inference
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Orthologs include human PSMD4, yeast RPN10, Arabidopsis, Drosophila
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.
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RPN-10 serves as ubiquitin receptor delivering substrates to 26S proteasome
"The ubiquitin-binding RPN-10 protein serves as a ubiquitin receptor that delivers client proteins to the 26S proteasome"
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rpn-10 knockdown causes feminization by eliminating hermaphrodite spermatogenesis
"We report herein that knockdown of the rpn-10 gene, but not any other proteasome subunit genes, sexually transforms hermaphrodites to females by eliminating hermaphrodite spermatogenesis in Caenorhabditis elegans"
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TRA-2 protein accumulates in rpn-10-defective worms
"TRA-2 proteins accumulated in rpn-10-defective worms"
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Genetic interaction with ufd-2 in sex determination pathway
"co-knockdown of rpn-10 and functionally related ubiquitin ligase ufd-2 overcomes the germline-musculinizing effect of fem-3(gf)"
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RPN-10-mediated pathway is essential for TRA-2 regulation
"Our results show that the RPN-10-mediated ubiquitin pathway is indispensable for control of the TRA-2-mediated sex-determining pathway"
Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway.
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RPN-10 localizes to cytoplasm and nucleus
"RPN-10 is expressed broadly and localizes to the cytoplasm and nucleus"
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RPN-10 is broadly expressed and contributes to UPS activity
"RPN-10 is broadly expressed and contributes to UPS activity"
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Loss of rpn-10 activates compensatory autophagy-lysosome pathway
"the rpn-10 mutant also shows enhanced activity of the autophagy-lysosome pathway as evidenced by increased expression of the multiple autophagy genes including atg-16.2, lgg-1, and bec-1"
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rpn-10 mutants show enhanced stress resistance and increased longevity
"develop both increased longevity and enhanced resistance to multiple threats to the proteome, including heat, oxidative stress, and the presence of aggregation prone proteins"
A photoconvertible reporter of the ubiquitin-proteasome system in vivo.
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RPN-10 involvement in UPS may be cell type specific
"UPS-mediated protein degradation varies in a cell type-specific and age-dependent manner in C. elegans"
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Required for protein degradation
"The ubiquitin-proteasome system (UPS) orchestrates many cellular and tissue-specific processes by degrading damaged and key regulatory proteins"
Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans.
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Paternal mitochondria and mtDNA are destroyed within two hours after fertilization in wild-type animals
"paternal mitochondria and mtDNA are destroyed within two hours after fertilization"
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In animals with compromised lysosomes, paternal mitochondria persist until late embryonic stages
"In animals with compromised lysosomes, paternal mitochondria persist until late embryonic stages"
Deep research report on rpn-10