Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

UniProt record for Pten (O08586)

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

Combined Automated Annotation using Multiple IEA Methods

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.

Pten regulates neuronal arborization and social interaction in mice.

Essential role for nuclear PTEN in maintaining chromosomal integrity.

A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities.

Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells.

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.

Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.

The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination.

Regulation of PTEN stability and activity by Plk3.

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.

Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.

Pten knockdown in vivo increases excitatory drive onto dentate granule cells.

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain.

Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells.

mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.

PTEN degradation after ischemic stroke: a double-edged sword.

PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility.

Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.

Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis.

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems.

Deep research report on Pten

BioReason deep research report on Pten

Falcon deep research summary for mouse Pten

AIGR curator notes for Pten