Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.
Cloning and characterization of a novel human Aurora C splicing variant.
Aurora A, centrosome structure, and the centrosome cycle.
Toward an understanding of the protein interaction network of the human liver.
Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Aurora C is directly associated with Survivin and required for cytokinesis.
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.
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A human founder AURKC coding deletion produces a truncated protein lacking the kinase domain in men with macrozoospermia-associated infertility.
"yielding a truncated
protein that lacks the kinase domain"
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
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Mouse Aurkb single conditional knockout and Aurkc single knockout retain fertility in this setting, whereas combined deficiency disrupts meiotic progression. Human evidence uses combined kinase inhibition.
"both Aurkb conditional knockout and Aurkc knockout
mouse spermatocytes successfully progress through meiosis, and the mice are
fertile."
Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.
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Human mitotic-cell experiments support INCENP interaction, passenger localization and overlapping Aurora-B/Aurora-C cytokinesis functions.
"Aurora-C could
rescue the Aurora-B silenced multinucleation phenotype"
A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development.
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Human oocyte and embryo observations identify prominent Aurora-C-containing CPC in the first three embryonic cell cycles, followed by a developmental shift toward Aurora-B.
"Aurora C becomes the most prominent kinase in the CPC"
Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.
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HeLa experiments support Aurora-C/TACC1 association and midbody colocalization, with in-vitro phosphorylation of TACC1 Ser228.
"TACC1 is phosphorylated by
Aurora-C on a serine at position 228"
A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis.