Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Combined Automated Annotation using Multiple IEA Methods

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells.

Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder.

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

A protein domain-based interactome network for C. elegans early embryogenesis.

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.

Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells.

Toward an understanding of the protein interaction network of the human liver.

Networks of bZIP protein-protein interactions diversified over a billion years of evolution.

A proteome-scale map of the human interactome network.

CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells.

The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2.

APR3 modulates oxidative stress and mitochondrial function in ARPE-19 cells.

A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.

FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

ARD1 stabilizes NRF2 through direct interaction and promotes colon cancer progression.

Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway.

Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced Failure of Neural Tube Closure.

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling.

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy.

Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation.

Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3.

DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway.

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.

Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.

Nrf2, the Major Regulator of the Cellular Oxidative Stress Response, is Partially Disordered.

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor.

The endoplasmic reticulum stress response in aging and age-related diseases.

The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing.

Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3.

The role of oxidative stress in Parkinson's disease.

HO-1 underlies resistance of AML cells to TNF-induced apoptosis.

Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner.

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene.

PRKAA2 phosphorylates nuclear NRF2

26S proteasome degrades ubiquitinated NRF2

KEAP1:CUL3:RBX1 complex ubiquitinates NRF2

VCP/p97 complex extracts ubiquitinated NRF2 for degradation

Ubiquitinated NRF2 extraction from CRL3 complex

PRKAA2-regulated nuclear export of NRF2

PKC phosphorylates NRF2 in cytosol

NRF2 binds KEAP1:NEDD8-CUL3:RBX1 in cytosol

NRF2 inducers bind KEAP1:CUL3:RBX1:NRF2 in cytosol

MYC and NICD1-dependent NFE2L2 gene expression

NFkB-dependent NFE2L2 expression

NFE2L2-dependent NFE2L2 expression (autoregulation)

Deep research report on NFE2L2