RRT2 / DPH7 / ERE1 (YBR246W, P38332) notes

Module diphthamide_biosynthesis, step 3 (EC 3.1.1.97 diphthine methylesterase).

• ybr246w accumulates diphthine PMID:22188241.
• Methylesterase PMID:24739148; not the synthetase [PMID:24739148 "Dph7 is not the diphthamide synthetase, as it lacks the ATP-binding domain required."; PMID:23169644 "it lacks an ATP-dependent catalytic domain"].
• Moonlighting as Ere1 in retromer recycling of Can1 PMID:21880895; mostly cytoplasmic, transiently endosomal PMID:21880895.
• Reactome R-SCE-5367021 describes cytosolic RRT2 demethylating Me-diphthine EFT1.

Observations: YeastCyc DIPHTINE--AMMONIA-LIGASE-RXN (EC 6.3.1.14) is assigned to RRT2 citing PMID:22188241; this is wrong (DPH6 is the ligase). The derived RCA GO:0017178 is REMOVED. Endosome / endocytic recycling kept as non-core.