Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells.
RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila.
Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery.
Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline.
RNAi components are required for nuclear clustering of Polycomb group response elements.
Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome.
The role of PIWI and the miRNA machinery in Drosophila germline determination.
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.
Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends.
Drosophila PIWI associates with chromatin and interacts directly with HP1a.
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line.
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila.
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo.
The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells.
PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition.
Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.
A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
Separation of stem cell maintenance and transposon silencing functions of Piwi protein.
Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line.
The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila.
Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression.
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state.
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary.
Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.
Panoramix enforces piRNA-dependent cotranscriptional silencing.
Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery.
Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila.
Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries.
Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells.
Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi.
A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila.
Maelstrom Represses Canonical Polymerase II Transcription within Bi-directional piRNA Clusters in Drosophila melanogaster.
Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery.
Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation.
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.
Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation.
Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila.
Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis.
Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci.
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster.
A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation.
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Piwi forms a complex with Hsp90 (Hsp83) and Hop, and the piRNA pathway, acting through this complex, suppresses phenotypic variation (canalization) in a sensitized eye-outgrowth assay.
"Our data indicate that Hsp90 and Hop regulate the piRNA pathway through Piwi to mediate canalization."
UniProtKB entry Q9VKM1 (PIWI_DROME)